Molecule Details
| InChIKey | MZWIXTAQIAHGBV-UHFFFAOYSA-N |
|---|---|
| Compound Name | 2-[4-(7-Ethoxy-2,3-bis-hydroxymethyl-6-methoxy-naphthalen-1-yl)-pyridin-2-yl]-4-pyridin-3-yl-2H-phthalazin-1-one; hydrochloride |
| Canonical SMILES | CCOc1cc2c(-c3ccnc(-n4nc(-c5cccnc5)c5ccccc5c4=O)c3)c(CO)c(CO)cc2cc1OC |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 7 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 8.27 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (7)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P27815 | PDE4A | Homo sapiens | Human | PF18100 PF00233 | 9.8 | IC50 | ChEMBL |
| Q07343 | PDE4B | Homo sapiens | Human | PF18100 PF00233 | 9.8 | IC50 | ChEMBL;BindingDB |
| Q08493 | PDE4C | Homo sapiens | Human | PF18100 PF00233 | 9.8 | IC50 | ChEMBL |
| Q08499 | PDE4D | Homo sapiens | Human | PF18100 PF00233 | 9.8 | IC50 | ChEMBL |
| Q13370 | PDE3B | Homo sapiens | Human | PF00233 | 6.3 | IC50 | ChEMBL |
| Q14432 | PDE3A | Homo sapiens | Human | PF00233 | 6.3 | IC50 | ChEMBL;BindingDB |
| O76074 | PDE5A | Homo sapiens | Human | PF01590 PF00233 | 6.1 | IC50 | ChEMBL;BindingDB |