3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl)phenol

InChIKey	`MZPDPRITYJNRSG-ZEQRLZLVSA-N`
Compound Name	3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl)phenol
Canonical SMILES	`CN1C[C@@H]2C[C@H]1CN2c1ccc(-c2ccnc3c(-c4cccc(O)c4)c(-c4ccncc4)nn23)cc1`
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	8
Pfam Stratification	Cross-Family
Avg pChEMBL	7.03
Source	ChEMBL;BindingDB;TTD_MultiTarget

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P15056	BRAF	Homo sapiens	Human	PF00130 PF07714 PF02196	9.4	IC50	ChEMBL;BindingDB
Q16539	MAPK14	Homo sapiens	Human	PF00069	7.2	IC50	ChEMBL;BindingDB
P05771	PRKCB	Homo sapiens	Human	PF00130 PF00168 PF00069 PF00433	6.9	IC50	ChEMBL;BindingDB
P00519	ABL1	Homo sapiens	Human	PF08919 PF07714 PF00017 PF00018	6.2	IC50	ChEMBL;BindingDB
P18505	GABRB1	Homo sapiens	Human	PF02931 PF02932	6.2	pIC50	TTD_MultiTarget
P12931	SRC	Homo sapiens	Human	PF07714 PF00017 PF00018	6.2	IC50	ChEMBL;BindingDB
O96017	CHEK2	Homo sapiens	Human	PF00498 PF00069	Clinical	TTD_MultiTarget	TTD_MultiTarget
P08581	MET	Homo sapiens	Human	PF07714 PF01437 PF01403 PF01833	Clinical	TTD_MultiTarget	TTD_MultiTarget