Molecule Details
InChIKeyMZDKLVOWGIOKTN-UHFFFAOYSA-N
Compound NamePF-562271
Canonical SMILESCN(c1ncccc1CNc1nc(Nc2ccc3c(c2)CC(=O)N3)ncc1C(F)(F)F)S(C)(=O)=O
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)80
Pfam Stratification Cross-Family
Avg pChEMBL6.68
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (80)
Target Gene Organism Category Pfam pChEMBL Type Source
Q05397 PTK2 Homo sapiens Human PF21477 PF00373 PF18038 PF03623 PF07714 8.8 IC50 ChEMBL;BindingDB
Q9P289 STK26 Homo sapiens Human PF20929 PF00069 7.9 Kd ChEMBL
P08922 ROS1 Homo sapiens Human PF00041 PF07714 7.9 Ki ChEMBL
Q14289 PTK2B Homo sapiens Human PF21477 PF00373 PF18038 PF03623 PF07714 7.9 IC50 ChEMBL;BindingDB
P50613 CDK7 Homo sapiens Human PF00069 7.7 Ki ChEMBL
Q04759 PRKCQ Homo sapiens Human PF00130 PF21494 PF00069 PF00433 7.7 Kd ChEMBL
P42685 FRK Homo sapiens Human PF07714 PF00017 PF00018 7.4 Ki ChEMBL
Q16620 NTRK2 Homo sapiens Human PF07679 PF13855 PF16920 PF01462 PF07714 7.4 Ki ChEMBL
P06493 CDK1 Homo sapiens Human PF00069 7.2 Ki ChEMBL
P28482 MAPK1 Homo sapiens Human PF00069 7.2 Ki ChEMBL
P50750 CDK9 Homo sapiens Human PF00069 7.2 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 7.2 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 7.2 Ki ChEMBL
O60674 JAK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 7.1 Ki ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 7.1 Ki ChEMBL
Q08881 ITK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 7.1 Ki ChEMBL
Q14680 MELK Homo sapiens Human PF02149 PF00069 PF21594 7.1 Ki ChEMBL
Q96L34 MARK4 Homo sapiens Human PF02149 PF00069 PF00627 7.1 Kd ChEMBL
Q00535 CDK5 Homo sapiens Human PF00069 7.1 Kd ChEMBL
Q00537 CDK17 Homo sapiens Human PF00069 7.0 Kd ChEMBL
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 7.0 Ki ChEMBL
P42679 MATK Homo sapiens Human PF07714 PF00017 PF00018 7.0 Ki ChEMBL
P49760 CLK2 Homo sapiens Human PF00069 6.9 Ki ChEMBL
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 6.9 Ki ChEMBL
O75716 STK16 Homo sapiens Human PF00069 6.9 Kd ChEMBL
P17612 PRKACA Homo sapiens Human PF00069 6.8 Ki ChEMBL
Q5S007 LRRK2 Homo sapiens Human PF23745 PF23744 PF23748 PF16095 PF25497 PF13855 PF00069 PF08477 6.8 Ki ChEMBL
O96013 PAK4 Homo sapiens Human PF00786 PF00069 6.7 Ki ChEMBL
P27448 MARK3 Homo sapiens Human PF02149 PF00069 PF00627 6.7 Ki ChEMBL
P30530 AXL Homo sapiens Human PF00041 PF13927 PF07714 6.7 Ki ChEMBL
Q02779 MAP3K10 Homo sapiens Human PF07714 PF14604 6.7 Ki ChEMBL
Q7L7X3 TAOK1 Homo sapiens Human PF00069 6.7 Ki ChEMBL
Q9H0K1 SIK2 Homo sapiens Human PF00069 PF23312 6.7 Ki ChEMBL
Q9H2X6 HIPK2 Homo sapiens Human PF00069 6.7 Ki ChEMBL
Q9UM73 ALK Homo sapiens Human PF12810 PF00629 PF07714 6.7 Ki ChEMBL
P08581 MET Homo sapiens Human PF07714 PF01437 PF01403 PF01833 6.6 Ki ChEMBL
P35916 FLT4 Homo sapiens Human PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.6 Ki ChEMBL
P53779 MAPK10 Homo sapiens Human PF00069 6.6 Ki ChEMBL
Q04912 MST1R Homo sapiens Human PF07714 PF01437 PF01403 PF01833 6.6 Ki ChEMBL
Q9H2G2 SLK Homo sapiens Human PF00069 PF12474 6.6 Ki ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 6.6 Kd ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 6.6 Kd ChEMBL
O14965 AURKA Homo sapiens Human PF00069 6.5 Kd ChEMBL
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 6.5 Ki ChEMBL
P29376 LTK Homo sapiens Human PF12810 PF07714 6.5 Ki ChEMBL
P29597 TYK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.5 Ki ChEMBL
Q7KZI7 MARK2 Homo sapiens Human PF02149 PF00069 PF00627 6.5 Ki ChEMBL
Q96RR4 CAMKK2 Homo sapiens Human PF00069 6.5 Ki ChEMBL
P49759 CLK1 Homo sapiens Human PF00069 6.4 Kd ChEMBL
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 6.4 Kd ChEMBL
P04629 NTRK1 Homo sapiens Human PF13855 PF16920 PF07714 PF18613 6.4 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.4 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 6.4 Ki ChEMBL
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 6.4 Ki ChEMBL
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 6.4 Ki ChEMBL
Q9NWZ3 IRAK4 Homo sapiens Human PF07714 6.4 Ki ChEMBL
Q16584 MAP3K11 Homo sapiens Human PF07714 PF14604 6.3 Kd ChEMBL
P06213 INSR Homo sapiens Human PF00757 PF17870 PF07714 PF01030 6.3 Ki ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 6.3 Ki ChEMBL
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 6.3 Ki ChEMBL
P51812 RPS6KA3 Homo sapiens Human PF00069 PF00433 6.3 Ki ChEMBL
Q13188 STK3 Homo sapiens Human PF11629 PF00069 6.3 Ki ChEMBL
Q8NE63 HIPK4 Homo sapiens Human PF00069 6.3 Ki ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 6.2 Ki ChEMBL
P11362 FGFR1 Homo sapiens Human PF07679 PF00047 PF07714 6.2 Ki ChEMBL
P22607 FGFR3 Homo sapiens Human PF21165 PF07679 PF13927 PF07714 6.2 Ki ChEMBL
Q15831 STK11 Homo sapiens Human PF00069 6.2 Kd ChEMBL
Q8N4C8 MINK1 Homo sapiens Human PF00780 PF00069 6.2 Ki ChEMBL
O96017 CHEK2 Homo sapiens Human PF00498 PF00069 6.1 Ki ChEMBL
P08069 IGF1R Homo sapiens Human PF00757 PF07714 PF01030 6.1 Ki ChEMBL
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.1 Ki ChEMBL
P51817 PRKX Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q16513 PKN2 Homo sapiens Human PF02185 PF00069 PF00433 6.1 Ki ChEMBL
P16591 FER Homo sapiens Human PF00611 PF07714 PF00017 6.1 Kd ChEMBL
O15530 PDPK1 Homo sapiens Human PF14593 PF00069 6.0 Ki ChEMBL
O43293 DAPK3 Homo sapiens Human PF00069 6.0 Ki ChEMBL
P09619 PDGFRB Homo sapiens Human PF00047 PF13927 PF25305 PF07714 6.0 Ki ChEMBL
P19784 CSNK2A2 Homo sapiens Human PF00069 6.0 Kd ChEMBL
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.0 Ki ChEMBL
P68400 CSNK2A1 Homo sapiens Human PF00069 6.0 Ki ChEMBL