Molecule Details
| InChIKey | MYWUZJCMWCOHBA-VIFPVBQESA-N |
|---|---|
| Compound Name | Methamphetamine |
| Canonical SMILES | CN[C@@H](C)Cc1ccccc1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.22 |
| Source | BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB01577 |
|---|---|
| Drug Name | Metamfetamine |
| CAS Number | 537-46-2 |
| Groups | approved illicit investigational withdrawn |
| ATC Codes | N06BA03 |
| Description | Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due ... |
Categories: Adrenergic Agents Adrenergic Agonists Adrenergic Uptake Inhibitors Adrenergic alpha-2 Receptor Agonists Adrenergic alpha-Agonists Agents producing tachycardia Agents that produce hypertension Amines Amphetamine Anorectic Amphetamines Antidepressive Agents Appetite Suppression Autonomic Agents Central Nervous System Agents Central Nervous System Depressants Central Nervous System Stimulants Central Nervous System Stimulation Centrally Acting Sympathomimetics Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 Substrates Dopamine Agents Dopamine Uptake Inhibitors Drugs that are Mainly Renally Excreted Ethylamines Increased Sympathetic Activity Membrane Transport Modulators Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates Nervous System Neurotransmitter Agents Neurotransmitter Uptake Inhibitors Peripheral Nervous System Agents Phenethylamines Psychoanaleptics Psychostimulants, Agents Used for ADHD and Nootropics Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Sympathomimetics
Cross-references: BindingDB: 50359499 ChEBI: 6809 CHEMBL1201201 ChemSpider: 10379 C07164 PDB: B40 PharmGKB: PA450403 PubChem:10836 PubChem:46508541 RxCUI: 6816 Therapeutic Targets Database: DAP001496 Wikipedia: Methamphetamine ZINC: ZINC000006021043
Target Activities (3)
DrugBank Target Actions (16)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P10635 | CYP2D6 | Cytochrome P450 2D6 | substrate | enzymes |
| P08913 | ADRA2A | Alpha-2A adrenergic receptor | agonist | targets |
| P14416 | DRD2 | D(2) dopamine receptor | agonist | targets |
| P18089 | ADRA2B | Alpha-2B adrenergic receptor | agonist | targets |
| P18825 | ADRA2C | Alpha-2C adrenergic receptor | agonist | targets |
| Q96RJ0 | TAAR1 | Trace amine-associated receptor 1 | agonist | targets |
| P35368 | ADRA1B | Alpha-1B adrenergic receptor | antagonist | targets |
| P21397 | MAOA | Amine oxidase [flavin-containing] A | inhibitor | targets |
| P27338 | MAOB | Amine oxidase [flavin-containing] B | inhibitor | targets |
| P54219 | P54219 | Chromaffin granule amine transporter | inhibitor | targets |
| Q05940 | SLC18A2 | Synaptic vesicular amine transporter | inhibitor | targets |
| P23975 | SLC6A2 | Sodium-dependent noradrenaline transporter | negative modulator | targets |
| P31645 | SLC6A4 | Sodium-dependent serotonin transporter | negative modulator | targets |
| Q01959 | SLC6A3 | Sodium-dependent dopamine transporter | negative modulator | targets |
| O75751 | SLC22A3 | Solute carrier family 22 member 3 | inhibitor | transporters |
| O76082 | O76082 | Organic cation/carnitine transporter 2 | inhibitor | transporters |