Molecule Details
InChIKeyMYWUZJCMWCOHBA-VIFPVBQESA-N
Compound NameMethamphetamine
Canonical SMILESCN[C@@H](C)Cc1ccccc1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Homologous
Avg pChEMBL7.22
SourceBindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB01577
Drug NameMetamfetamine
CAS Number537-46-2
Groups approved illicit investigational withdrawn
ATC Codes N06BA03
DescriptionMetamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due ...

Categories: Adrenergic Agents Adrenergic Agonists Adrenergic Uptake Inhibitors Adrenergic alpha-2 Receptor Agonists Adrenergic alpha-Agonists Agents producing tachycardia Agents that produce hypertension Amines Amphetamine Anorectic Amphetamines Antidepressive Agents Appetite Suppression Autonomic Agents Central Nervous System Agents Central Nervous System Depressants Central Nervous System Stimulants Central Nervous System Stimulation Centrally Acting Sympathomimetics Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 Substrates Dopamine Agents Dopamine Uptake Inhibitors Drugs that are Mainly Renally Excreted Ethylamines Increased Sympathetic Activity Membrane Transport Modulators Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates Nervous System Neurotransmitter Agents Neurotransmitter Uptake Inhibitors Peripheral Nervous System Agents Phenethylamines Psychoanaleptics Psychostimulants, Agents Used for ADHD and Nootropics Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Sympathomimetics
Cross-references: BindingDB: 50359499 ChEBI: 6809 CHEMBL1201201 ChemSpider: 10379 C07164 PDB: B40 PharmGKB: PA450403 PubChem:10836 PubChem:46508541 RxCUI: 6816 Therapeutic Targets Database: DAP001496 Wikipedia: Methamphetamine ZINC: ZINC000006021043
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
P23975 SLC6A2 Homo sapiens Human PF00209 7.9 Ki BindingDB
Q01959 SLC6A3 Homo sapiens Human PF00209 7.6 Ki BindingDB
P31645 SLC6A4 Homo sapiens Human PF03491 PF00209 6.1 Ki BindingDB
DrugBank Target Actions (16)
Target Gene Target Name Action Type
P10635 CYP2D6 Cytochrome P450 2D6 substrate enzymes
P08913 ADRA2A Alpha-2A adrenergic receptor agonist targets
P14416 DRD2 D(2) dopamine receptor agonist targets
P18089 ADRA2B Alpha-2B adrenergic receptor agonist targets
P18825 ADRA2C Alpha-2C adrenergic receptor agonist targets
Q96RJ0 TAAR1 Trace amine-associated receptor 1 agonist targets
P35368 ADRA1B Alpha-1B adrenergic receptor antagonist targets
P21397 MAOA Amine oxidase [flavin-containing] A inhibitor targets
P27338 MAOB Amine oxidase [flavin-containing] B inhibitor targets
P54219 P54219 Chromaffin granule amine transporter inhibitor targets
Q05940 SLC18A2 Synaptic vesicular amine transporter inhibitor targets
P23975 SLC6A2 Sodium-dependent noradrenaline transporter negative modulator targets
P31645 SLC6A4 Sodium-dependent serotonin transporter negative modulator targets
Q01959 SLC6A3 Sodium-dependent dopamine transporter negative modulator targets
O75751 SLC22A3 Solute carrier family 22 member 3 inhibitor transporters
O76082 O76082 Organic cation/carnitine transporter 2 inhibitor transporters