Molecule Details
| InChIKey | MXYUKLILVYORSK-HBMCJLEFSA-N |
|---|---|
| Compound Name | Lobeline |
| Canonical SMILES | CN1[C@@H](CC(=O)c2ccccc2)CCC[C@H]1C[C@H](O)c1ccccc1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.84 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB05137 |
|---|---|
| Drug Name | Lobeline |
| CAS Number | 90-69-7 |
| Groups | investigational |
| ATC Codes | nan |
| Description | An alkaloid that has actions similar to nicotine on nicotinic cholinergic receptors but is less potent. It has been proposed for a variety of therapeutic uses including in respiratory disorders, peripheral vascular disorders, insomnia, and smoking cessation. [PubChem] |
Categories: Alkaloids Autonomic Agents Cholinergic Agents Cholinergic Agonists Ganglionic Stimulants Neurotransmitter Agents Nicotinic Agonists Peripheral Nervous System Agents Piperidines Respiratory System Agents
Cross-references: BindingDB: 50080818 ChEBI: 48723 CHEMBL122270 ChemSpider: 91814 C07475 D02364 PDB: L0B PubChem:101616 PubChem:175426951 RxCUI: 6464 Wikipedia: Lobeline ZINC: ZINC000000001624
Target Activities (3)
DrugBank Target Actions (4)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P36544 | CHRNA7 | Neuronal acetylcholine receptor subunit alpha-7 | binder | targets |
| Q9GZZ6 | CHRNA10 | Neuronal acetylcholine receptor subunit alpha-10 | binder | targets |
| Q9UGM1 | CHRNA9 | Neuronal acetylcholine receptor subunit alpha-9 | binder | targets |
| Q05940 | SLC18A2 | Synaptic vesicular amine transporter | inhibitor | targets |