Molecule Details
InChIKeyMXWDSZWTBOCWBK-UHFFFAOYSA-N
Compound Name4-(dimethylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)benzamide
Canonical SMILESCN(C)c1ccc(C(=O)NCCCCCCC(=O)NO)cc1
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)13
Pfam Stratification Cross-Family
Avg pChEMBL7.35
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB02565
Drug Name4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide
CAS Number251456-60-7
Groups experimental
ATC Codes nan
Descriptionnan

Categories: Amides Amines Anilides Aniline Compounds Antineoplastic Agents Enzyme Inhibitors Histone Deacetylase Inhibitors Hydroxamic Acids Hydroxy Acids Hydroxylamines
Cross-references: BindingDB: 50082665 ChEBI: 125562 CHEMBL140000 ChemSpider: 3856 PDB: B3N PubChem:3994 PubChem:46507995 ZINC: ZINC000012502280
Target Activities (13)
Target Gene Organism Category Pfam pChEMBL Type Source
O15379 HDAC3 Homo sapiens Human PF00850 8.4 IC50 ChEMBL;BindingDB
Q13547 HDAC1 Homo sapiens Human PF00850 7.7 IC50 ChEMBL;BindingDB
Q92769 HDAC2 Homo sapiens Human PF00850 7.7 IC50 ChEMBL;BindingDB
P56524 HDAC4 Homo sapiens Human PF12203 PF00850 7.3 pIC50 TTD_MultiTarget
Q02161 RHD Homo sapiens Human PF00909 7.3 pIC50 TTD_MultiTarget
Q8WUI4 HDAC7 Homo sapiens Human PF00850 7.3 IC50 ChEMBL
Q969S8 HDAC10 Homo sapiens Human PF00850 7.3 IC50 ChEMBL
Q96DB2 HDAC11 Homo sapiens Human PF00850 7.3 IC50 ChEMBL
Q9BY41 HDAC8 Homo sapiens Human PF00850 7.3 IC50 ChEMBL
Q9UKV0 HDAC9 Homo sapiens Human PF12203 PF00850 7.3 IC50 ChEMBL
Q9UQL6 HDAC5 Homo sapiens Human PF12203 PF00850 7.3 IC50 ChEMBL
Q9UBN7 HDAC6 Homo sapiens Human PF00850 PF02148 6.7 IC50 ChEMBL;BindingDB
P09960 LTA4H Homo sapiens Human PF09127 PF01433 PF17900 6.3 IC50 ChEMBL;BindingDB
DrugBank Target Actions (3)
Target Gene Target Name Action Type
Q9BY41 HDAC8 Histone deacetylase 8 binder targets
P14416 DRD2 D(2) dopamine receptor inhibitor targets
P35462 DRD3 D(3) dopamine receptor inhibitor targets