Molecule Details
| InChIKey | MXSDIGYURCYKOV-UHFFFAOYSA-N |
|---|---|
| Compound Name | 3-(N-[8-chloro-7-(1-methylpyrazol-4-yl)-1,5-naphthyridin-2-yl]-3,5-dimethoxyanilino)propan-1-ol |
| Canonical SMILES | COc1cc(OC)cc(N(CCCO)c2ccc3ncc(-c4cnn(C)c4)c(Cl)c3n2)c1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 5 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 8.96 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (5)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P21802 | FGFR2 | Homo sapiens | Human | PF07679 PF13927 PF07714 | 9.9 | IC50 | ChEMBL;BindingDB |
| P22607 | FGFR3 | Homo sapiens | Human | PF21165 PF07679 PF13927 PF07714 | 9.3 | IC50 | ChEMBL;BindingDB |
| P11362 | FGFR1 | Homo sapiens | Human | PF07679 PF00047 PF07714 | 9.1 | IC50 | ChEMBL;BindingDB |
| P22455 | FGFR4 | Homo sapiens | Human | PF07679 PF13927 PF07714 | 8.7 | IC50 | ChEMBL;BindingDB |
| P35968 | KDR | Homo sapiens | Human | PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 | 7.8 | IC50 | ChEMBL;BindingDB |