InChIKey	MXAYKZJJDUDWDS-LBPRGKRZSA-N
Compound Name	Ixazomib
Canonical SMILES	CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B(O)O
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	22
Pfam Stratification	Cross-Family
Avg pChEMBL	7.9
Source	ChEMBL;BindingDB

DrugBank ID	DB09570
Drug Name	Ixazomib
CAS Number	1072833-77-2
Groups	approved investigational
ATC Codes	L01XG03
Description	Ixazomib is a reversible proteasome inhibitor. Because it is a modified peptide boronic acid with one chiral center,[A264329] it is considered a boronate proteasome inhibitor.[A7948] More than 99% of the drug compound is the R-enantiomer.[A264329] Ixazomib was approved by the FDA on November 20, 201...

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Categories: Antineoplastic Agents Antineoplastic and Immunomodulating Agents Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP2B6 Substrates Cytochrome P-450 CYP2B6 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP2C8 Substrates Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index Cytochrome P-450 Substrates Drugs that are Mainly Renally Excreted Narrow Therapeutic Index Drugs P-glycoprotein substrates P-glycoprotein substrates with a Narrow Therapeutic Index Proteasome Inhibitors

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Cross-references: BindingDB: 50398609 ChEBI: 90942 CHEMBL2141296 ChemSpider: 25027391 Drugs Product Database (DPD): 22810 D10130 PDB: 6V8 PubChem:25183872 PubChem:310265228 RxCUI: 1723735 Wikipedia: Ixazomib ZINC: ZINC000169946773