InChIKey	MVWVFYHBGMAFLY-UHFFFAOYSA-N
Compound Name	Ziprasidone
Canonical SMILES	O=C1Cc2cc(CCN3CCN(c4nsc5ccccc45)CC3)c(Cl)cc2N1
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	31
Pfam Stratification	Cross-Family
Avg pChEMBL	7.43
Source	BindingDB;ChEMBL;TTD_MultiTarget

DrugBank ID	DB00246
Drug Name	Ziprasidone
CAS Number	146939-27-7
Groups	approved investigational
ATC Codes	N05AE04
Description	Disorders such as schizophrenia and bipolar disorder can significantly impair mood, cognition, and behavior.[A190525] These mental illnesses can often be accompanied by comorbidities such as depression and substance abuse, and can significantly impact the quality of life of patients and caregivers.[...

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Categories: Adrenergic Antagonists Adrenergic alpha-1 Receptor Antagonists Adrenergic alpha-Antagonists Agents that produce hypertension Anticholinergic Agents Antidepressive Agents Antipsychotic Agents Antipsychotic Agents (Second Generation [Atypical]) Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (weak) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (moderate) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A4 Substrates (strength unknown) Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dopamine Agents Dopamine Antagonists Dopamine D2 Receptor Antagonists Highest Risk QTc-Prolonging Agents Histamine Antagonists Histamine H1 Antagonists Hyperglycemia-Associated Agents Indole Derivatives Muscarinic Antagonists Nervous System Neurotoxic agents Neurotransmitter Agents Psycholeptics Psychotropic Drugs QTc Prolonging Agents Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Serotonin 5-HT1 Receptor Agonists Serotonin 5-HT1 Receptor Antagonists Serotonin 5-HT1D Receptor Antagonists Serotonin 5-HT2 Receptor Antagonists Serotonin 5-HT2A Receptor Antagonists Serotonin 5-HT2C Receptor Antagonists Serotonin Agents Serotonin Receptor Agonists Serotonin Receptor Antagonists Sulfur Compounds Tranquilizing Agents

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Cross-references: BindingDB: 50048803 ChEBI: 10119 CHEMBL708 ChemSpider: 54841 Drugs Product Database (DPD): 11753 Guide to Pharmacology: 59 IUPHAR: 59 C07568 D08687 PDB: XEF PharmGKB: PA451974 PubChem:60854 PubChem:46507627 RxCUI: 115698 Therapeutic Targets Database: DAP000079 Wikipedia: Ziprasidone ZINC: ZINC000000538550