Molecule Details
| InChIKey | MVMQESMQSYOVGV-UHFFFAOYSA-N |
|---|---|
| Compound Name | (+-)-Dimethindene |
| Canonical SMILES | CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 6 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.05 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB08801 |
|---|---|
| Drug Name | Dimetindene |
| CAS Number | 5636-83-9 |
| Groups | approved investigational |
| ATC Codes | R06AB03 D04AA13 |
| Description | Dimetindene (Fenistil) is an antihistamine/anticholinergic used orally and locally as an antipruritic. |
Categories: Agents producing tachycardia Anti-Allergic Agents Anticholinergic Agents Antihistamines for Systemic Use Antihistamines for Topical Use Antipruritics Antipruritics, Incl. Antihistamines, Anesthetics, Etc. Dermatologicals Histamine Agents Histamine Antagonists Histamine H1 Antagonists Indenes Muscarinic Antagonists Neurotransmitter Agents Pyridines Substituted Alkylamines
Cross-references: BindingDB: 81452 ChEBI: 135222 CHEMBL22108 ChemSpider: 20541 D07853 PharmGKB: PA165958420 PubChem:21855 PubChem:99445271 RxCUI: 3449 Wikipedia: Dimetindene
Target Activities (6)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P35367 | HRH1 | Homo sapiens | Human | PF00001 | 9.2 | Ki | ChEMBL;BindingDB |
| P08172 | CHRM2 | Homo sapiens | Human | PF00001 | 7.3 | Ki | ChEMBL;BindingDB |
| P20309 | CHRM3 | Homo sapiens | Human | PF00001 | 6.7 | Ki | ChEMBL;BindingDB |
| P11229 | CHRM1 | Homo sapiens | Human | PF00001 | 6.6 | Ki | ChEMBL;BindingDB |
| P08173 | CHRM4 | Homo sapiens | Human | PF00001 | 6.4 | Ki | ChEMBL;BindingDB |
| P08912 | CHRM5 | Homo sapiens | Human | PF00001 | 6.1 | Ki | ChEMBL;BindingDB |