Molecule Details
InChIKeyMUTBJZVSRNUIHA-UHFFFAOYSA-N
Compound NameR-306465
Canonical SMILESO=C(NO)c1cnc(N2CCN(S(=O)(=O)c3ccc4ccccc4c3)CC2)nc1
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)12
Pfam Stratification Cross-Family
Avg pChEMBL7.93
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB12382
Drug NameR-306465
CAS Number604769-01-9
Groups investigational
ATC Codes nan
DescriptionR306465 has been used in trials studying the treatment of Neoplasms.
Categories: Amines Antineoplastic Agents Enzyme Inhibitors Histone Deacetylase Inhibitors Hydroxy Acids Hydroxylamines Sulfur Compounds
Cross-references: BindingDB: 50304782 CHEMBL609583 ChemSpider: 8485365 PubChem:10309899 PubChem:347828630 ZINC: ZINC000003818418
Target Activities (12)
Target Gene Organism Category Pfam pChEMBL Type Source
Q96DB2 HDAC11 Homo sapiens Human PF00850 8.7 IC50 ChEMBL;BindingDB
Q13547 HDAC1 Homo sapiens Human PF00850 8.6 pIC50 TTD_MultiTarget
Q969S8 HDAC10 Homo sapiens Human PF00850 8.4 IC50 ChEMBL;BindingDB
P56524 HDAC4 Homo sapiens Human PF12203 PF00850 8.3 IC50 ChEMBL;BindingDB
Q9UQL6 HDAC5 Homo sapiens Human PF12203 PF00850 8.2 IC50 ChEMBL;BindingDB
O15379 HDAC3 Homo sapiens Human PF00850 8.1 IC50 ChEMBL;BindingDB
Q92769 HDAC2 Homo sapiens Human PF00850 8.1 pIC50 TTD_MultiTarget
Q9BY41 HDAC8 Homo sapiens Human PF00850 7.6 IC50 ChEMBL;BindingDB
Q9UKV0 HDAC9 Homo sapiens Human PF12203 PF00850 7.5 IC50 ChEMBL;BindingDB
Q8WUI4 HDAC7 Homo sapiens Human PF00850 7.3 IC50 ChEMBL;BindingDB
Q02161 RHD Homo sapiens Human PF00909 7.2 pIC50 TTD_MultiTarget
Q9UBN7 HDAC6 Homo sapiens Human PF00850 PF02148 7.2 IC50 ChEMBL;BindingDB