InChIKey	MUGXRYIUWFITCP-PGRDOPGGSA-N
Canonical SMILES	Cc1ncc(OC[C@@]2(c3cccc(F)c3)C[C@H]2C(=O)Nc2ccc(F)cn2)c(C)n1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	2
Pfam Stratification	Homologous
Avg pChEMBL	8.77
Source	ChEMBL;BindingDB

DrugBank ID	DB11951
Drug Name	Lemborexant
CAS Number	1369764-02-2
Groups	approved investigational
ATC Codes	N05CJ02
Description	Lemborexant is a novel dual orexin receptor antagonist used in the treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance.[L10863] Recent research in the field of sleep disorders has revealed that insomnia is likely driven not by the inability of the brain to "...

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Categories: Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Hypnotics and Sedatives Nervous System Neurotransmitter Agents Orexin Receptor Antagonists P-glycoprotein substrates Psycholeptics Sleep Aids, Pharmaceutical Sleep Initiation and Maintenance Disorders

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Cross-references: BindingDB: 50093793 CHEMBL3545367 ChemSpider: 34500836 Drugs Product Database (DPD): 23527 PDB: NRK PubChem:56944144 PubChem:347828277 RxCUI: 2272403 Wikipedia: Lemborexant ZINC: ZINC000118073503