Molecule Details
InChIKeyMUCZHBLJLSDCSD-UHFFFAOYSA-N
Compound NameDiisopropyl Fluorophosphate
Canonical SMILESCC(C)OP(=O)(F)OC(C)C
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Cross-Family
Avg pChEMBL6.68
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB00677
Drug NameIsoflurophate
CAS Number55-91-4
Groups approved withdrawn
ATC Codes nan
DescriptionAn irreversible cholinesterase inhibitor with actions similar to those of echothiophate. It is a powerful miotic used mainly in the treatment of glaucoma. Its vapor is highly toxic and it is recommended that only solutions in arachis oil be used therapeutically. (From Martindale, The Extra Pharmacop...

Categories: Cholinergic Agents Cholinesterase Inhibitors Enzyme Inhibitors Neurotransmitter Agents Ophthalmics Organofluorophosphonates Organophosphonates Organophosphorus Compounds Protease Inhibitors
Cross-references: BindingDB: 50022772 ChEBI: 17941 CHEMBL1025 ChemSpider: 5723 C00202 D00043 PharmGKB: PA164748933 PubChem:5936 PubChem:46504499 RxCUI: 6027 Therapeutic Targets Database: DAP000896 Wikipedia: Diisopropyl_fluorophosphate ZINC: ZINC000008214587
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
P22303 ACHE Homo sapiens Human PF08674 PF00135 6.9 IC50 ChEMBL;BindingDB
P35354 PTGS2 Homo sapiens Human PF03098 6.4 Ki BindingDB
DrugBank Target Actions (5)
Target Gene Target Name Action Type
P02768 ALB Albumin binder carriers
P06276 BCHE Cholinesterase inhibitor enzymes
P02787 P02787 Serotransferrin binder targets
P06276 BCHE Cholinesterase inhibitor targets
P22303 ACHE Acetylcholinesterase inhibitor targets