Molecule Details
| InChIKey | MRDYEAJRUPFRFX-UHFFFAOYSA-N |
|---|---|
| Compound Name | 3-[4-(2,4-dimethyl-1,3-thiazol-5-yl)phenyl]-8-[(3-methyl-2-pyridinyl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dione |
| Canonical SMILES | Cc1nc(C)c(-c2ccc(N3C(=O)N(c4cc(O)ncn4)C4(CCN(Cc5ncccc5C)CC4)C3=O)cc2)s1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 8.18 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q96KS0 | EGLN2 | Homo sapiens | Human | PF13640 | 9.4 | IC50 | ChEMBL;BindingDB |
| Q9GZT9 | EGLN1 | Homo sapiens | Human | PF13640 PF01753 | 9.1 | IC50 | ChEMBL;BindingDB |
| Q9H6Z9 | EGLN3 | Homo sapiens | Human | PF13640 | 8.2 | IC50 | ChEMBL;BindingDB |
| Q12809 | KCNH2 | Homo sapiens | Human | PF00027 PF00520 PF13426 | 6.0 | IC50 | ChEMBL;BindingDB |