Molecule Details
| InChIKey | MRAUNPAHJZDYCK-BYPYZUCNSA-N |
|---|---|
| Compound Name | Nomega-nitro-L-arginine |
| Canonical SMILES | N=C(NCCC[C@H](N)C(=O)O)N[N+](=O)[O-] |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 6.59 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB04223 |
|---|---|
| Drug Name | Nitroarginine |
| CAS Number | 2149-70-4 |
| Groups | investigational |
| ATC Codes | nan |
| Description | An inhibitor of nitric oxide synthetase which has been shown to prevent glutamate toxicity. Nitroarginine has been experimentally tested for its ability to prevent ammonia toxicity and ammonia-induced alterations in brain energy and ammonia metabolites. (Neurochem Res 1995:200(4):451-6) |
Categories: Amino Acids Amino Acids, Basic Amino Acids, Diamino Amino Acids, Peptides, and Proteins Arginine Enzyme Inhibitors
Cross-references: BindingDB: 50225106 ChEBI: 27960 CHEMBL227744 ChemSpider: 389023 C03417 PDB: NRG PubChem:440005 PubChem:46508354 Wikipedia: Nitroarginine ZINC: ZINC000019796052
Target Activities (3)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P29475 | NOS1 | Homo sapiens | Human | PF00667 PF00258 PF00175 PF02898 PF00595 | 7.1 | IC50 | ChEMBL;BindingDB |
| P29474 | NOS3 | Homo sapiens | Human | PF00667 PF00258 PF00175 PF02898 | 6.5 | IC50 | ChEMBL;BindingDB |
| P35228 | NOS2 | Homo sapiens | Human | PF00667 PF00258 PF00175 PF02898 | 6.2 | Ki | ChEMBL;BindingDB |