InChIKey	MQJKPEGWNLWLTK-UHFFFAOYSA-N
Canonical SMILES	Nc1ccc(S(=O)(=O)c2ccc(N)cc2)cc1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	2
Pfam Stratification	Cross-Family
Avg pChEMBL	6.56
Source	ChEMBL;BindingDB

DrugBank ID	DB00250
Drug Name	Dapsone
CAS Number	80-08-0
Groups	approved investigational
ATC Codes	J04BA50 J04BA51 D10AX05 J04BA02
Description	A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine i...

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Categories: Anti-Acne Preparations Anti-Acne Preparations for Topical Use Anti-Bacterial Agents Anti-Infective Agents Antibiotics for Pneumocystis Pneumonia Antiinfectives for Systemic Use Antimalarials Antimycobacterials Antiparasitic Agents Antiprotozoals Cytochrome P-450 CYP2C18 Substrates Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C8 Substrates Cytochrome P-450 CYP2C9 Inducers Cytochrome P-450 CYP2C9 Inducers (strength unknown) Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP2E1 Substrates Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Substrates Dermatologicals Drugs causing inadvertant photosensitivity Drugs for Treatment of Lepra Enzyme Inhibitors Folic Acid Antagonists Leprostatic Agents Methemoglobinemia Associated Agents Miscellaneous Antimycobacterials Miscellaneous Local Anti-infectives Photosensitizing Agents Sulfones Sulfur Compounds

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Cross-references: BindingDB: 50029764 ChEBI: 4325 CHEMBL1043 ChemSpider: 2849 Drugs Product Database (DPD): 8120 C07666 D00592 PharmGKB: PA449211 PubChem:2955 PubChem:46505300 RxCUI: 3108 Therapeutic Targets Database: DAP000637 Wikipedia: Dapsone ZINC: ZINC000000006310