[3-Cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl]amino]carbonyl]phenyl]pentafluorosulfur

InChIKey	`MPASHPJAIUOWCK-UHFFFAOYSA-N`
Compound Name	[3-Cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl]amino]carbonyl]phenyl]pentafluorosulfur
Canonical SMILES	`Cc1cc(C)c(-n2ccn3nc(-c4cccnc4)cc23)cc1NC(=O)c1cc(C#N)cc(S(F)(F)(F)(F)F)c1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	9
Pfam Stratification	Cross-Family
Avg pChEMBL	7.85
Source	ChEMBL;BindingDB

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
Q08345	DDR1	Homo sapiens	Human	PF21114 PF00754 PF07714	9.4	Kd	ChEMBL
Q02763	TEK	Homo sapiens	Human	PF00041 PF10430 PF07714	9.2	IC50	ChEMBL;BindingDB
P35590	TIE1	Homo sapiens	Human	PF00041 PF00047 PF07714	9.1	Kd	ChEMBL
Q16832	DDR2	Homo sapiens	Human	PF21114 PF00754 PF07714	8.9	Kd	ChEMBL
O94804	STK10	Homo sapiens	Human	PF00069 PF12474	8.2	Kd	ChEMBL
P41145	OPRK1	Homo sapiens	Human	PF00001	6.9	Ki	ChEMBL
P14867	GABRA1	Homo sapiens	Human	PF02931 PF02932	6.7	Ki	ChEMBL
P35916	FLT4	Homo sapiens	Human	PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854	6.4	IC50	ChEMBL
Q5BJF2	TMEM97	Homo sapiens	Human	PF05241	6.0	Ki	ChEMBL