Molecule Details
| InChIKey | MLYYVTUWGNIJIB-BXKDBHETSA-N |
|---|---|
| Canonical SMILES | Cc1nnc(SCC2=C(C(=O)O)N3C(=O)[C@@H](NC(=O)Cn4cnnn4)[C@H]3SC2)s1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 6.5 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB01327 |
|---|---|
| Drug Name | Cefazolin |
| CAS Number | 25953-19-9 |
| Groups | approved investigational |
| ATC Codes | J01DB04 |
| Description | A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine. |
Categories: Amides Anti-Bacterial Agents Anti-Infective Agents Antibacterials for Systemic Use Antiinfectives for Systemic Use Cephalosporins First-Generation Cephalosporins Heterocyclic Compounds, Fused-Ring Lactams Nephrotoxic agents OAT1/SLC22A6 Substrates OAT1/SLC22A6 inhibitors OAT3/SLC22A8 Inhibitors OAT3/SLC22A8 Substrates Sulfur Compounds Thiazines beta-Lactams
Cross-references: BindingDB: 50370587 ChEBI: 474053 CHEMBL1435 ChemSpider: 30723 Drugs Product Database (DPD): 11180 C06880 D02299 PDB: X56 PharmGKB: PA448839 PubChem:33255 PubChem:46506123 RxCUI: 2180 Therapeutic Targets Database: DAP000449 Wikipedia: Cefazolin ZINC: ZINC000003830405
Target Activities (2)
DrugBank Target Actions (15)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P02768 | ALB | Albumin | other/unknown | carriers |
| P51580 | TPMT | Thiopurine S-methyltransferase | substrate | enzymes |
| P02918 | P02918 | Penicillin-binding protein 1A | inhibitor | targets |
| P02919 | P02919 | Penicillin-binding protein 1B | inhibitor | targets |
| P0AD65 | mrdA | Peptidoglycan D,D-transpeptidase MrdA | inhibitor | targets |
| P0AD68 | P0AD68 | Peptidoglycan D,D-transpeptidase FtsI | inhibitor | targets |
| P27169 | P27169 | Serum paraoxonase/arylesterase 1 | inhibitor | targets |
| P40933 | IL15 | Interleukin-15 | inhibitor | targets |
| P60568 | IL2 | Interleukin-2 | inhibitor | targets |
| P76577 | P76577 | Penicillin-binding protein 1C | inhibitor | targets |
| Q4U2R8 | SLC22A6 | Solute carrier family 22 member 6 | inhibitor | transporters |
| Q8TCC7 | SLC22A8 | Organic anion transporter 3 | inhibitor | transporters |
| Q9NSA0 | SLC22A11 | Solute carrier family 22 member 11 | inhibitor | transporters |
| O15439 | O15439 | ATP-binding cassette sub-family C member 4 | substrate | transporters |
| Q4U2R8 | SLC22A6 | Solute carrier family 22 member 6 | substrate | transporters |