Molecule Details
InChIKeyMLKXDPUZXIRXEP-MFOYZWKCSA-N
Compound NameSulindac
Canonical SMILESCC1=C(CC(=O)O)c2cc(F)ccc2/C1=C\c1ccc([S+](C)[O-])cc1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Cross-Family
Avg pChEMBL6.33
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB00605
Drug NameSulindac
CAS Number38194-50-2
Groups approved investigational
ATC Codes M01AB02
DescriptionSulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid class that is marketed by Merck under the brand name Clinoril. Like other NSAIDs, it may be used in the treatment of acute or chronic inflammatory conditions. Sulindac is a prodrug, derived from sulfinylindene, that i...

Categories: Acetic Acid Derivatives and Related Substances Agents causing hyperkalemia Agents that produce hypertension Analgesics Analgesics, Non-Narcotic Anti-Inflammatory Agents Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal (Non-Selective) Antiinflammatory and Antirheumatic Products Antiinflammatory and Antirheumatic Products, Non-Steroids Antirheumatic Agents Cyclooxygenase Inhibitors Drugs causing inadvertant photosensitivity Enzyme Inhibitors Indenes Musculo-Skeletal System Nephrotoxic agents Non COX-2 selective NSAIDS OAT1/SLC22A6 inhibitors Other Nonsteroidal Anti-inflammatory Agents Peripheral Nervous System Agents Photosensitizing Agents Sensory System Agents
Cross-references: BindingDB: 50103504 ChEBI: 9352 CHEMBL15770 ChemSpider: 1265915 Drugs Product Database (DPD): 2126 C01531 D00120 PharmGKB: PA451565 PubChem:1548887 PubChem:46506570 RxCUI: 10237 Therapeutic Targets Database: DAP000569 Wikipedia: Sulindac
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
P15121 AKR1B1 Homo sapiens Human PF00248 6.4 IC50 ChEMBL;BindingDB
P01031 C5 Homo sapiens Human PF00207 PF07703 PF07677 PF01821 PF21309 PF17790 PF01835 PF17791 PF17789 PF01759 PF07678 6.2 Kd ChEMBL;BindingDB
DrugBank Target Actions (10)
Target Gene Target Name Action Type
P02768 ALB Albumin binder carriers
P04798 CYP1A1 Cytochrome P450 1A1 inhibitor enzymes
Q9Y5Y4 PTGDR2 Prostaglandin D2 receptor 2 antagonist targets
O60218 AKR1B10 Aldo-keto reductase family 1 member B10 inhibitor targets
P15121 AKR1B1 Aldo-keto reductase family 1 member B1 inhibitor targets
P23219 PTGS1 Prostaglandin G/H synthase 1 inhibitor targets
P27361 MAPK3 Mitogen-activated protein kinase 3 inhibitor targets
P35354 PTGS2 Prostaglandin G/H synthase 2 inhibitor targets
Q03181 PPARD Peroxisome proliferator-activated receptor delta negative modulator targets
Q4U2R8 SLC22A6 Solute carrier family 22 member 6 inhibitor transporters