Molecule Details
| InChIKey | MLKXDPUZXIRXEP-MFOYZWKCSA-N |
|---|---|
| Compound Name | Sulindac |
| Canonical SMILES | CC1=C(CC(=O)O)c2cc(F)ccc2/C1=C\c1ccc([S+](C)[O-])cc1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.33 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB00605 |
|---|---|
| Drug Name | Sulindac |
| CAS Number | 38194-50-2 |
| Groups | approved investigational |
| ATC Codes | M01AB02 |
| Description | Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid class that is marketed by Merck under the brand name Clinoril. Like other NSAIDs, it may be used in the treatment of acute or chronic inflammatory conditions. Sulindac is a prodrug, derived from sulfinylindene, that i... |
Categories: Acetic Acid Derivatives and Related Substances Agents causing hyperkalemia Agents that produce hypertension Analgesics Analgesics, Non-Narcotic Anti-Inflammatory Agents Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal (Non-Selective) Antiinflammatory and Antirheumatic Products Antiinflammatory and Antirheumatic Products, Non-Steroids Antirheumatic Agents Cyclooxygenase Inhibitors Drugs causing inadvertant photosensitivity Enzyme Inhibitors Indenes Musculo-Skeletal System Nephrotoxic agents Non COX-2 selective NSAIDS OAT1/SLC22A6 inhibitors Other Nonsteroidal Anti-inflammatory Agents Peripheral Nervous System Agents Photosensitizing Agents Sensory System Agents
Cross-references: BindingDB: 50103504 ChEBI: 9352 CHEMBL15770 ChemSpider: 1265915 Drugs Product Database (DPD): 2126 C01531 D00120 PharmGKB: PA451565 PubChem:1548887 PubChem:46506570 RxCUI: 10237 Therapeutic Targets Database: DAP000569 Wikipedia: Sulindac
Target Activities (2)
DrugBank Target Actions (10)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P02768 | ALB | Albumin | binder | carriers |
| P04798 | CYP1A1 | Cytochrome P450 1A1 | inhibitor | enzymes |
| Q9Y5Y4 | PTGDR2 | Prostaglandin D2 receptor 2 | antagonist | targets |
| O60218 | AKR1B10 | Aldo-keto reductase family 1 member B10 | inhibitor | targets |
| P15121 | AKR1B1 | Aldo-keto reductase family 1 member B1 | inhibitor | targets |
| P23219 | PTGS1 | Prostaglandin G/H synthase 1 | inhibitor | targets |
| P27361 | MAPK3 | Mitogen-activated protein kinase 3 | inhibitor | targets |
| P35354 | PTGS2 | Prostaglandin G/H synthase 2 | inhibitor | targets |
| Q03181 | PPARD | Peroxisome proliferator-activated receptor delta | negative modulator | targets |
| Q4U2R8 | SLC22A6 | Solute carrier family 22 member 6 | inhibitor | transporters |