InChIKey	MLDQJTXFUGDVEO-UHFFFAOYSA-N
Compound Name	Sorafenib
Canonical SMILES	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	85
Pfam Stratification	Cross-Family
Avg pChEMBL	6.98
Source	BindingDB;ChEMBL;TTD_MultiTarget

DrugBank ID	DB00398
Drug Name	Sorafenib
CAS Number	284461-73-0
Groups	approved investigational
ATC Codes	L01EX02
Description	Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis.[A255852] First approved by the FDA and European Commission in 2007 for the t...

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Categories: Amides Antineoplastic Agents Antineoplastic and Immunomodulating Agents BCRP/ABCG2 Inhibitors BCRP/ABCG2 Substrates Benzene Derivatives Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP2B6 Inhibitors Cytochrome P-450 CYP2B6 Inhibitors (moderate) Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 inhibitors (strength unknown) Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (strength unknown) Cytochrome P-450 CYP2C8 Inhibitors (strong) Cytochrome P-450 CYP2C8 Substrates Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strong) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strength unknown) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 CYP3A7 Substrates with a Narrow Therapeutic Index Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Drugs that are Mainly Renally Excreted Enzyme Inhibitors Immunosuppressive Agents Kinase Inhibitor Myelosuppressive Agents Narrow Therapeutic Index Drugs Nicotinic Acids OATP1B1/SLCO1B1 Inhibitors P-glycoprotein inhibitors P-glycoprotein substrates P-glycoprotein substrates with a Narrow Therapeutic Index Phenylurea Compounds Potential QTc-Prolonging Agents Protein Kinase Inhibitors Pyridines QTc Prolonging Agents Tyrosine Kinase Inhibitors UGT1A1 Inhibitors UGT1A9 Inhibitors UGT1A9 Substrates UGT1A9 Substrates with a Narrow Therapeutic Index

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Cross-references: BindingDB: 16673 ChEBI: 50924 CHEMBL1336 ChemSpider: 187440 Drugs Product Database (DPD): 15231 D08524 PDB: BAX PharmGKB: PA7000 PubChem:216239 PubChem:46505329 RxCUI: 495881 Therapeutic Targets Database: DAP000006 Wikipedia: Sorafenib ZINC: ZINC000001493878