InChIKey	MKXZASYAUGDDCJ-NJAFHUGGSA-N
Compound Name	Dextromethorphan
Canonical SMILES	COc1ccc2c(c1)[C@]13CCCC[C@@H]1[C@H](C2)N(C)CC3
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Cross-Family
Avg pChEMBL	7.51
Source	ChEMBL

DrugBank ID	DB00514
Drug Name	Dextromethorphan
CAS Number	125-71-3
Groups	approved investigational
ATC Codes	N06AX62 R05DA09 N07XX59
Description	Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse.[A215412] Although similar in structure to other opioids, it has minimal interaction with opioid receptors.[A215412] Dextromethorphan was granted FDA approval before 3 Decemb...

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Categories: Alkaloids Anticholinergic Agents Antidepressive Agents Antitussive Agents Central Nervous System Agents Central Nervous System Depressants Combined Inhibitors of Serotonin/Norepinephrine Reuptake Cough and Cold Preparations Cytochrome P-450 CYP2B6 Substrates Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Substrates Excitatory Amino Acid Agents Excitatory Amino Acid Antagonists Heterocyclic Compounds, Fused-Ring Morphinans NMDA Receptor Antagonists Nervous System Neurotransmitter Agents Nicotinic Antagonists Opiate Alkaloids Opioids Opium Alkaloids and Derivatives Phenanthrenes Psychoanaleptics Respiratory System Agents Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Serotonin Agents Serotonin Modulators Sigma-1 Agonist Sigma-1 Receptor Agonists UGT2B17 substrates UGT2B7 substrates Uncompetitive N-methyl-D-aspartate Receptor Antagonist Uncompetitive NMDA Receptor Antagonists

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Cross-references: BindingDB: 50366613 ChEBI: 4470 CHEMBL52440 ChemSpider: 13109865 Drugs Product Database (DPD): 10247 C06947 D03742 PharmGKB: PA449273 PubChem:5360696 PubChem:46506530 RxCUI: 3289 Therapeutic Targets Database: DNC000541 Wikipedia: Dextromethorphan ZINC: ZINC000003201907