Molecule Details
InChIKeyMIKAKZKNMYZLDX-UHFFFAOYSA-N
Compound Namen-Cyclopropyl-n-[(4-oxo4,5-dihydropyrrolo[1,2-a]quinoxalin-8-yl)methyl]methanesulfonamide
Canonical SMILESCS(=O)(=O)N(Cc1ccc2[nH]c(=O)c3cccn3c2c1)C1CC1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)42
Pfam Stratification Cross-Family
Avg pChEMBL6.89
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (42)
Target Gene Organism Category Pfam pChEMBL Type Source
P53350 PLK1 Homo sapiens Human PF00069 PF00659 8.0 Ki ChEMBL
Q8IW41 MAPKAPK5 Homo sapiens Human PF00069 8.0 Ki ChEMBL
P68400 CSNK2A1 Homo sapiens Human PF00069 7.8 Ki ChEMBL
Q9H4B4 PLK3 Homo sapiens Human PF00069 PF00659 7.8 Ki ChEMBL
P04626 ERBB2 Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 7.5 Ki ChEMBL
P31749 AKT1 Homo sapiens Human PF00169 PF00069 PF00433 7.5 Ki ChEMBL
Q96PF2 TSSK2 Homo sapiens Human PF00069 7.4 Ki ChEMBL
Q9NR20 DYRK4 Homo sapiens Human PF00069 7.4 Ki ChEMBL
P08922 ROS1 Homo sapiens Human PF00041 PF07714 7.3 Ki ChEMBL
Q16644 MAPKAPK3 Homo sapiens Human PF00069 7.3 Ki ChEMBL
Q9H2X6 HIPK2 Homo sapiens Human PF00069 7.2 Ki ChEMBL
O15530 PDPK1 Homo sapiens Human PF14593 PF00069 7.1 Ki ChEMBL
P31751 AKT2 Homo sapiens Human PF00169 PF00069 PF00433 7.1 Ki ChEMBL
P42679 MATK Homo sapiens Human PF07714 PF00017 PF00018 7.1 Ki ChEMBL
P49137 MAPKAPK2 Homo sapiens Human PF00069 7.1 Ki ChEMBL
Q9Y243 AKT3 Homo sapiens Human PF00169 PF00069 PF00433 7.1 Ki ChEMBL
O00311 CDC7 Homo sapiens Human PF00069 7.0 Ki ChEMBL
O43781 DYRK3 Homo sapiens Human PF00069 6.8 Ki ChEMBL
P07332 FES Homo sapiens Human PF00611 PF07714 PF00017 6.8 Ki ChEMBL
P51617 IRAK1 Homo sapiens Human PF00531 PF00069 6.8 Ki ChEMBL
Q9Y6M4 CSNK1G3 Homo sapiens Human PF12605 PF00069 6.8 Ki ChEMBL
Q14680 MELK Homo sapiens Human PF02149 PF00069 PF21594 6.7 Ki ChEMBL
Q8TDC3 BRSK1 Homo sapiens Human PF21122 PF00069 PF21115 6.7 Ki ChEMBL
Q96SB4 SRPK1 Homo sapiens Human PF00069 6.7 Ki ChEMBL
Q9BZL6 PRKD2 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.7 Ki ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 6.6 Ki ChEMBL
O15264 MAPK13 Homo sapiens Human PF00069 6.6 Ki ChEMBL
P10721 KIT Homo sapiens Human PF00047 PF07714 6.6 Ki ChEMBL
P51957 NEK4 Homo sapiens Human PF00069 6.6 Ki ChEMBL
Q13555 CAMK2G Homo sapiens Human PF08332 PF00069 6.6 Ki ChEMBL
Q13557 CAMK2D Homo sapiens Human PF08332 PF00069 6.6 Ki ChEMBL
Q13976 PRKG1 Homo sapiens Human PF00027 PF16808 PF00069 6.6 Ki ChEMBL
Q9NYL2 MAP3K20 Homo sapiens Human PF07714 PF07647 6.6 Ki ChEMBL
P43405 SYK Homo sapiens Human PF07714 PF00017 6.5 Ki ChEMBL
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 6.5 Ki ChEMBL
P53778 MAPK12 Homo sapiens Human PF00069 6.5 Ki ChEMBL
P00533 EGFR Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.3 Ki ChEMBL
Q13237 PRKG2 Homo sapiens Human PF00027 PF00069 6.3 Ki ChEMBL
Q8NE63 HIPK4 Homo sapiens Human PF00069 6.3 Ki ChEMBL
Q9H3Y6 SRMS Homo sapiens Human PF07714 PF00017 6.2 Ki ChEMBL
Q9HCP0 CSNK1G1 Homo sapiens Human PF12605 PF00069 6.2 Ki ChEMBL
Q9HBH9 MKNK2 Homo sapiens Human PF00069 6.1 Ki ChEMBL