Molecule Details
| InChIKey | MHZIGJBWNNGGBZ-UHFFFAOYSA-N |
|---|---|
| Compound Name | 4-[3-chloro-4-(cyclopropylcarbamoylamino)-2,6-difluorophenoxy]-7-methoxy-N-(2,2,2-trifluoroethyl)quinoline-6-carboxamide |
| Canonical SMILES | COc1cc2nccc(Oc3c(F)cc(NC(=O)NC4CC4)c(Cl)c3F)c2cc1C(=O)NCC(F)(F)F |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.79 |
| Source | BindingDB |
2D Structure
Activity Profile
Target Activities (3)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P07949 | RET | Homo sapiens | Human | PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 | 8.1 | IC50 | BindingDB |
| P17948 | FLT1 | Homo sapiens | Human | PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 | 8.1 | IC50 | BindingDB |
| P21802 | FGFR2 | Homo sapiens | Human | PF07679 PF13927 PF07714 | 7.1 | IC50 | BindingDB |