Molecule Details
InChIKeyMEXUTNIFSHFQRG-UHFFFAOYSA-N
Compound NameK-252C
Canonical SMILESO=C1NCc2c1c1c3ccccc3[nH]c1c1[nH]c3ccccc3c21
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)21
Pfam Stratification Cross-Family
Avg pChEMBL6.69
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB08036
Drug Name6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one
CAS Numbernan
Groups experimental
ATC Codes nan
Descriptionnan

Cross-references: BindingDB: 2581 CHEMBL16958 ChemSpider: 3683 PDB: K2C PubChem:3815 PubChem:99444507 ZINC: ZINC000002560264
Target Activities (21)
Target Gene Organism Category Pfam pChEMBL Type Source
Q16584 MAP3K11 Homo sapiens Human PF07714 PF14604 7.3 IC50 ChEMBL;BindingDB
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 7.2 IC50 ChEMBL;BindingDB
P80192 MAP3K9 Homo sapiens Human PF07714 PF14604 6.9 IC50 ChEMBL;BindingDB
Q13554 CAMK2B Homo sapiens Human PF08332 PF00069 6.7 IC50 ChEMBL
Q13555 CAMK2G Homo sapiens Human PF08332 PF00069 6.7 IC50 ChEMBL
Q13557 CAMK2D Homo sapiens Human PF08332 PF00069 6.7 IC50 ChEMBL;BindingDB
Q9UQM7 CAMK2A Homo sapiens Human PF08332 PF00069 6.7 IC50 ChEMBL
O94806 PRKD3 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.7 IC50 ChEMBL
P05129 PRKCG Homo sapiens Human PF00130 PF00168 PF00069 PF00433 6.7 IC50 ChEMBL
P05771 PRKCB Homo sapiens Human PF00130 PF00168 PF00069 PF00433 6.7 IC50 ChEMBL
P17252 PRKCA Homo sapiens Human PF00130 PF00168 PF00069 PF00433 6.7 IC50 ChEMBL
P24723 PRKCH Homo sapiens Human PF00130 PF00168 PF00069 PF00433 6.7 IC50 ChEMBL
P41743 PRKCI Homo sapiens Human PF00130 PF00564 PF00069 PF00433 6.7 IC50 ChEMBL
Q02156 PRKCE Homo sapiens Human PF00130 PF00168 PF00069 PF00433 6.7 IC50 ChEMBL
Q04759 PRKCQ Homo sapiens Human PF00130 PF21494 PF00069 PF00433 6.7 IC50 ChEMBL
Q05513 PRKCZ Homo sapiens Human PF00130 PF00564 PF00069 PF00433 6.7 IC50 ChEMBL
Q05655 PRKCD Homo sapiens Human PF00130 PF21494 PF00069 PF00433 6.7 IC50 ChEMBL
Q15139 PRKD1 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.7 IC50 ChEMBL
P11802 CDK4 Homo sapiens Human PF00069 6.1 IC50 ChEMBL;BindingDB
P24385 CCND1 Homo sapiens Human PF02984 PF00134 6.1 IC50 ChEMBL
P18505 GABRB1 Homo sapiens Human PF02931 PF02932 Clinical TTD_MultiTarget TTD_MultiTarget
DrugBank Target Actions (1)
Target Gene Target Name Action Type
Q8KI25 Q8KI25 Putative FAD-monooxygenase binder targets