Molecule Details
InChIKeyMECMVUIPPJEYFL-UHFFFAOYSA-N
Compound Name1-[4-(5-bromo-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]-2-(4-chlorophenyl)-2-(4-methylpiperazin-1-yl)ethanone
Canonical SMILESCN1CCN(C(C(=O)N2CCN(c3ncnc4[nH]cc(Br)c34)CC2)c2ccc(Cl)cc2)CC1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Homologous
Avg pChEMBL8.17
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
P31749 AKT1 Homo sapiens Human PF00169 PF00069 PF00433 8.5 IC50 ChEMBL;BindingDB
Q9Y243 AKT3 Homo sapiens Human PF00169 PF00069 PF00433 8.3 IC50 ChEMBL;BindingDB
P31751 AKT2 Homo sapiens Human PF00169 PF00069 PF00433 7.7 IC50 ChEMBL;BindingDB