InChIKey	MDSQOJYHHZBZKA-GBXCKJPGSA-N
Canonical SMILES	CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	2
Pfam Stratification	Homologous
Avg pChEMBL	6.12
Source	ChEMBL;BindingDB

DrugBank ID	DB12095
Drug Name	Telotristat ethyl
CAS Number	1033805-22-9
Groups	approved investigational
ATC Codes	nan
Description	Telotristat ethyl is a prodrug of telotristat that was approved by the FDA in March 2017 as Xermelo.[L43342] It was previously referred to as telotristat etiprate, the hippurate salt form; however, the FDA recommends the use of the name of the neutral form rather than that of the salt.[A252937, A252...

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Categories: Antidiarrheals Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 inhibitors (strength unknown) Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (strength unknown) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strength unknown) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strength unknown) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors P-glycoprotein inhibitors P-glycoprotein substrates Tryptophan Hydroxylase Inhibitor UGT2B7 inducers

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Cross-references: BindingDB: 445704 CHEMBL2105695 ChemSpider: 28189674 Drugs Product Database (DPD): 23002 PubChem:25025298 PubChem:347828399 RxCUI: 1872441 Wikipedia: Telotristat_ethyl ZINC: ZINC000043205655