InChIKey	MCGSCOLBFJQGHM-SCZZXKLOSA-N
Canonical SMILES	Nc1nc(NC2CC2)c2ncn([C@H]3C=C[C@@H](CO)C3)c2n1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	2
Pfam Stratification	Homologous
Avg pChEMBL	6.89
Source	BindingDB;ChEMBL

DrugBank ID	DB01048
Drug Name	Abacavir
CAS Number	136470-78-5
Groups	approved investigational
ATC Codes	J05AR13 J05AR02 J05AR04 J05AF06
Description	Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. Chemically, it is a synthetic carbocyclic nucleoside and is the enantiomer with 1S, 4R absolute configuration on the cyclopentene ring. In vivo, abacavir sulfate dissociates to its free ...

---

Categories: Anti-HIV Agents Anti-Infective Agents Anti-Retroviral Agents Antiinfectives for Systemic Use Antiviral Agents Antivirals for Systemic Use Antivirals used in combination for the treatment of HIV infections Cycloparaffins Deoxyadenosines Deoxyribonucleosides Dideoxynucleosides Direct Acting Antivirals Drugs that are Mainly Renally Excreted Enzyme Inhibitors Heterocyclic Compounds, Fused-Ring Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor Nucleic Acid Synthesis Inhibitors Nucleic Acids, Nucleotides, and Nucleosides Nucleoside Reverse Transcriptase Inhibitors Nucleoside and Nucleotide Reverse Transcriptase Inhibitors Nucleosides Purine Nucleosides Purines Reverse Transcriptase Inhibitors UGT1A1 Substrates

---

Cross-references: BindingDB: 50366816 ChEBI: 421707 CHEMBL1380 ChemSpider: 390063 Drugs Product Database (DPD): 11893 C07624 D07057 PDB: 1KX PharmGKB: PA448004 PubChem:441300 PubChem:46505718 RxCUI: 190521 Therapeutic Targets Database: DAP000704 Wikipedia: Abacavir ZINC: ZINC000002015928