InChIKey	MBUVEWMHONZEQD-UHFFFAOYSA-N
Compound Name	Azelastine
Canonical SMILES	CN1CCCC(n2nc(Cc3ccc(Cl)cc3)c3ccccc3c2=O)CC1
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	17
Pfam Stratification	Cross-Family
Avg pChEMBL	6.84
Source	ChEMBL;BindingDB;TTD_MultiTarget

DrugBank ID	DB00972
Drug Name	Azelastine
CAS Number	58581-89-8
Groups	approved investigational
ATC Codes	R06AX19 S01GX07 R01AC03
Description	Azelastine, a phthalazine derivative, is an antihistamine available as an intranasal spray for the treatment of allergic and vasomotor rhinitis and as an ophthalmic solution for the treatment of allergic conjunctivitis.[L8240,L8270] It is a racemic mixture, though there is no noted difference in pha...

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Categories: Anti-Allergic Agents Antiallergic Agents, Excl. Corticosteroids Antihistamines for Systemic Use Autonomic Agents Central Nervous System Depressants Cytochrome P-450 CYP1A1 Substrates Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2A6 Inhibitors Cytochrome P-450 CYP2A6 Inhibitors (strength unknown) Cytochrome P-450 CYP2A6 Substrates Cytochrome P-450 CYP2B6 Inhibitors Cytochrome P-450 CYP2B6 Inhibitors (strength unknown) Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C19 inhibitors (strength unknown) Cytochrome P-450 CYP2C8 Substrates Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strength unknown) Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strength unknown) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP2E1 Inhibitors Cytochrome P-450 CYP2E1 Inhibitors (strength unknown) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Decongestants and Antiallergics Enzyme Inhibitors Histamine Agents Histamine Antagonists Histamine H1 Antagonists Histamine H1 Antagonists, Non-Sedating Nasal Preparations Neurotransmitter Agents Ophthalmologicals P-glycoprotein inhibitors Pyridazines Respiratory System Agents Sensory Organs

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Cross-references: BindingDB: 50341448 ChEBI: 2950 CHEMBL639 ChemSpider: 2180 Drugs Product Database (DPD): 22525 C07768 D07483 PharmGKB: PA448517 PubChem:2267 PubChem:46507582 RxCUI: 18603 Therapeutic Targets Database: DNC000270 Wikipedia: Azelastine