InChIKey	MBBCVAKAJPKAKM-UHFFFAOYSA-N
Canonical SMILES	O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	2
Pfam Stratification	Cross-Family
Avg pChEMBL	8.7
Source	ChEMBL;BindingDB

DrugBank ID	DB08827
Drug Name	Lomitapide
CAS Number	182431-12-5
Groups	approved investigational
ATC Codes	C10AX12
Description	Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R).

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Categories: Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (weak) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A4 Substrates (strength unknown) Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Hepatotoxic Agents Heterocyclic Compounds, Fused-Ring Hypolipidemic Agents Hypolipidemic Agents Indicated for Hyperlipidemia Lipid Modifying Agents Lipid Modifying Agents, Plain Microsomal Triglyceride Transfer Protein Inhibitor Microsomal Triglyceride Transfer Protein Inhibitors Narrow Therapeutic Index Drugs Non-statin Hypolipidemic Agents Indicated for Hyperlipidemia P-glycoprotein inhibitors

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Cross-references: BindingDB: 50098320 ChEBI: 72297 CHEMBL354541 ChemSpider: 8028764 Drugs Product Database (DPD): 22241 D09637 PharmGKB: PA166114922 PubChem:9853053 PubChem:175427108 RxCUI: 1364479 Wikipedia: Lomitapide ZINC: ZINC000027990463