Molecule Details
InChIKeyMADCXGNPDBWPLM-UHFFFAOYSA-N
Compound Name2-[4-(3-amino-1H-indazol-4-yl)phenyl]-N-(4-fluoro-3-methylphenyl)acetamide
Canonical SMILESCc1cc(NC(=O)Cc2ccc(-c3cccc4[nH]nc(N)c34)cc2)ccc1F
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)25
Pfam Stratification Cross-Family
Avg pChEMBL6.7
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (25)
Target Gene Organism Category Pfam pChEMBL Type Source
P36888 FLT3 Homo sapiens Human PF00047 PF07714 9.0 Ki ChEMBL
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 8.3 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 7.7 Ki ChEMBL
Q9UBE8 NLK Homo sapiens Human PF00069 7.3 Ki ChEMBL
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 7.2 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 7.1 Ki ChEMBL
P35916 FLT4 Homo sapiens Human PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.9 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 6.9 Ki ChEMBL
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 6.8 Ki ChEMBL
Q8NE63 HIPK4 Homo sapiens Human PF00069 6.8 Ki ChEMBL
O75582 RPS6KA5 Homo sapiens Human PF00069 PF00433 6.7 Ki ChEMBL
P42685 FRK Homo sapiens Human PF07714 PF00017 PF00018 6.6 Ki ChEMBL
P51817 PRKX Homo sapiens Human PF00069 6.5 Ki ChEMBL
Q13976 PRKG1 Homo sapiens Human PF00027 PF16808 PF00069 6.4 Ki ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 6.3 Ki ChEMBL
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 6.3 Ki ChEMBL
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 6.3 Ki ChEMBL
Q9HBH9 MKNK2 Homo sapiens Human PF00069 6.2 Ki ChEMBL
P17612 PRKACA Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q13188 STK3 Homo sapiens Human PF11629 PF00069 6.1 Ki ChEMBL
O14965 AURKA Homo sapiens Human PF00069 6.0 Ki ChEMBL
P49760 CLK2 Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q13237 PRKG2 Homo sapiens Human PF00027 PF00069 6.0 Ki ChEMBL
Q16620 NTRK2 Homo sapiens Human PF07679 PF13855 PF16920 PF01462 PF07714 6.0 Ki ChEMBL
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 6.0 Ki ChEMBL