InChIKey	LXMSZDCAJNLERA-ZHYRCANASA-N
Compound Name	Spironolactone
Canonical SMILES	CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@]34CCC(=O)O4)[C@H]12
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	6
Pfam Stratification	Cross-Family
Avg pChEMBL	6.89
Source	ChEMBL;BindingDB;TTD_MultiTarget

DrugBank ID	DB00421
Drug Name	Spironolactone
CAS Number	52-01-7
Groups	approved investigational
ATC Codes	C03DA01
Description	Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists.[A178192] It promotes sodium and water excretion and potassium retention.[A11837] Spironolactone was originally developed purely for this ability before other pharmacodyna...

---

Categories: Agents causing hyperkalemia Antihypertensive Agents Antihypertensive Agents Indicated for Hypertension BSEP/ABCB11 Substrates Cardiovascular Agents Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (moderate) Cytochrome P-450 Enzyme Inhibitors Diuretics Fused-Ring Compounds Hormone Antagonists Hormones, Hormone Substitutes, and Hormone Antagonists Hypotensive Agents Lactones Mineralocorticoid (Aldosterone) Receptor Antagonists Mineralocorticoid Receptor Antagonists Natriuretic Agents P-glycoprotein inducers Potassium-Sparing Diuretics Pregnanes Pregnenes Steroids

---

Cross-references: BindingDB: 50228080 ChEBI: 9241 CHEMBL1393 ChemSpider: 5628 Drugs Product Database (DPD): 7408 Guide to Pharmacology: 2875 IUPHAR: 2875 C07310 D00443 PDB: SNL PharmGKB: PA451483 PubChem:5833 PubChem:46508525 RxCUI: 9997 Therapeutic Targets Database: DAP000297 Wikipedia: Spironolactone ZINC: ZINC000003861599