Molecule Details
InChIKeyLUWQTRGZKXLDSO-AREMUKBSSA-N
Compound Name(1R)-1-[7-(2-fluoro-5-morpholin-4-ylanilino)-1,6-naphthyridin-2-yl]-1-(1-methylpiperidin-4-yl)ethanol
Canonical SMILESCN1CCC([C@@](C)(O)c2ccc3cnc(Nc4cc(N5CCOCC5)ccc4F)cc3n2)CC1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)11
Pfam Stratification Cross-Family
Avg pChEMBL7.29
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (11)
Target Gene Organism Category Pfam pChEMBL Type Source
Q00535 CDK5 Homo sapiens Human PF00069 9.2 IC50 ChEMBL
Q15078 CDK5R1 Homo sapiens Human PF03261 9.2 IC50 ChEMBL;BindingDB
P50613 CDK7 Homo sapiens Human PF00069 7.1 IC50 ChEMBL
P51946 CCNH Homo sapiens Human PF16899 PF00134 7.1 IC50 ChEMBL;BindingDB
P51948 MNAT1 Homo sapiens Human PF25811 PF06391 PF17121 7.1 IC50 ChEMBL
O60563 CCNT1 Homo sapiens Human PF00134 PF21797 6.9 IC50 ChEMBL;BindingDB
P50750 CDK9 Homo sapiens Human PF00069 6.9 IC50 ChEMBL
P20248 CCNA2 Homo sapiens Human PF02984 PF00134 PF16500 6.7 IC50 ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 6.7 IC50 ChEMBL;BindingDB
P30281 CCND3 Homo sapiens Human PF02984 PF00134 6.6 IC50 ChEMBL
Q00534 CDK6 Homo sapiens Human PF00069 6.6 IC50 ChEMBL;BindingDB