InChIKey	LTMHDMANZUZIPE-PUGKRICDSA-N
Compound Name	Digoxin
Canonical SMILES	C[C@H]1O[C@@H](O[C@H]2[C@@H](O)C[C@H](O[C@H]3[C@@H](O)C[C@H](O[C@H]4CC[C@@]5(C)[C@H](CC[C@@H]6[C@@H]5C[C@@H](O)[C@]5(C)[C@@H](C7=CC(=O)OC7)CC[C@]65O)C4)O[C@@H]3C)O[C@@H]2C)C[C@H](O)[C@@H]1O
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	10
Pfam Stratification	Cross-Family
Avg pChEMBL	6.74
Source	BindingDB;ChEMBL

DrugBank ID	DB00390
Drug Name	Digoxin
CAS Number	20830-75-5
Groups	approved investigational
ATC Codes	C01AA05
Description	Digoxin is one of the oldest cardiovascular medications used today.[A178225] It is a common agent used to manage atrial fibrillation and the symptoms of heart failure.[A178234] Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954.[L9143] This drug originates fro...

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Categories: Agents causing hyperkalemia Antiarrhythmic agents BSEP/ABCB11 Substrates BSEP/ABCB11 Substrates with a Narrow Therapeutic Index Bradycardia-Causing Agents Carbohydrates Cardanolides Cardenolides Cardiac Glycosides Cardiac Therapy Cardiotonic Agents Cardiovascular Agents Compounds used in a research, industrial, or household setting Digitalis Glycosides Digoxin and derivatives Digoxin, antagonists & inhibitors Digoxin, immunology Drugs that are Mainly Renally Excreted Drugs that are Mainly Renally Excreted with a Narrow Therapeutic Index Fused-Ring Compounds Glycosides Narrow Therapeutic Index Drugs OATP1B1/SLCO1B1 Inhibitors OATP1B1/SLCO1B1 Substrates P-glycoprotein inducers P-glycoprotein inhibitors P-glycoprotein substrates P-glycoprotein substrates with a Narrow Therapeutic Index Potential QTc-Prolonging Agents Protective Agents QTc Prolonging Agents

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Cross-references: BindingDB: 46355 ChEBI: 4551 CHEMBL1751 ChemSpider: 2006532 Drugs Product Database (DPD): 6731 C06956 D00298 PDB: DGX PharmGKB: PA449319 PubChem:2724385 PubChem:46508524 RxCUI: 3407 Therapeutic Targets Database: DAP000744 Wikipedia: Digoxin ZINC: ZINC000242548690