Molecule Details
| InChIKey | LTLYEAJONXGNFG-DCAQKATOSA-N |
|---|---|
| Compound Name | trans-Epoxysuccinyl-L-leucylamido-(4-guanidino)butane |
| Canonical SMILES | CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(=O)O)C(=O)NCCCCN=C(N)N |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 9 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.42 |
| Source | ChEMBL |
2D Structure
Activity Profile
Target Activities (9)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P43235 | CTSK | Homo sapiens | Human | PF08246 PF00112 | 8.4 | IC50 | ChEMBL |
| P25774 | CTSS | Homo sapiens | Human | PF08246 PF00112 | 8.2 | IC50 | ChEMBL |
| P07858 | CTSB | Homo sapiens | Human | PF00112 PF08127 | 8.0 | IC50 | ChEMBL |
| P07711 | CTSL | Homo sapiens | Human | PF08246 PF00112 | 7.5 | IC50 | ChEMBL |
| P07384 | CAPN1 | Homo sapiens | Human | PF01067 PF13833 PF00648 | 7.0 | IC50 | ChEMBL |
| P09668 | CTSH | Homo sapiens | Human | PF08246 PF00112 | 6.7 | IC50 | ChEMBL |
| P53634 | CTSC | Homo sapiens | Human | PF08773 PF00112 | 6.1 | IC50 | ChEMBL |
| Q95PM0 | rhodesain | Trypanosoma brucei rhodesiense | Pathogen | PF12131 PF08246 PF00112 | 8.0 | IC50 | ChEMBL |
| Q8IIL0 | FP3 | Plasmodium falciparum (isolate 3D7) | Pathogen | PF08246 PF00112 | 6.9 | IC50 | ChEMBL |