Molecule Details
InChIKeyLPQZKKCYTLCDGQ-WEDXCCLWSA-N
Compound NameTazobactam
Canonical SMILESC[C@]1(Cn2ccnn2)[C@H](C(=O)O)N2C(=O)C[C@H]2S1(=O)=O
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)15
Pfam Stratification Cross-Family
Avg pChEMBL7.14
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB01606
Drug NameTazobactam
CAS Number89786-04-9
Groups approved investigational
ATC Codes J01CG02
DescriptionTazobactam is an antibiotic of the beta-lactamase inhibitor class that prevents the breakdown of other antibiotics by beta-lactamase enzyme producing organisms. It is combined with [Piperacillin] and [Ceftolozane] for the treatment of a variety of bacterial infections. Piperacillin-tazobactam was in...

Categories: Amides Anti-Infective Agents Antibacterials for Systemic Use Antiinfectives for Systemic Use Aza Compounds Azabicyclo Compounds Beta-Lactam Antibacterials Enzyme Inhibitors Heterocyclic Compounds, Fused-Ring Lactams OAT1/SLC22A6 Substrates OAT1/SLC22A6 inhibitors OAT3/SLC22A8 Inhibitors OAT3/SLC22A8 Substrates Sulfones Sulfur Compounds beta-Lactamase Inhibitors beta-Lactams
Cross-references: BindingDB: 50053173 ChEBI: 9421 CHEMBL404 ChemSpider: 110216 Drugs Product Database (DPD): 11242 C07771 D00660 PDB: TAZ PharmGKB: PA164764504 PubChem:123630 PubChem:46508088 RxCUI: 37617 Therapeutic Targets Database: DAP000926 Wikipedia: Tazobactam ZINC: ZINC000003787060
Target Activities (15)
Target Gene Organism Category Pfam pChEMBL Type Source
Q9EXV5 blaUOE-1 Escherichia coli Pathogen PF13354 8.7 IC50 ChEMBL;BindingDB
Q2XPY6 blaCTX-M-53 Salmonella enterica subsp. enterica serovar Westhampton Pathogen PF13354 8.7 IC50 ChEMBL;BindingDB
A1E3K9 blaSCO-1 Escherichia coli Pathogen PF13354 8.0 IC50 ChEMBL;BindingDB
Q46991 imiA Enterobacter cloacae Pathogen PF13354 7.5 IC50 ChEMBL;BindingDB
Q670S6 Pseudomonas luteola Pathogen PF13354 7.4 IC50 ChEMBL;BindingDB
D1MIX9 blaGES-13 Pseudomonas aeruginosa Pathogen PF13354 7.2 IC50 ChEMBL;BindingDB
Q6W9J1 blaTEM-1 Enterobacter cloacae Pathogen PF13354 7.2 IC50 ChEMBL
A0ZX81 blaSHV-72 Klebsiella pneumoniae Pathogen PF13354 7.1 IC50 ChEMBL;BindingDB
Q8RT60 bla OXY Klebsiella oxytoca Pathogen PF13354 7.0 IC50 BindingDB
Q6GWS8 blaTEM-125 Escherichia coli Pathogen PF13354 6.6 IC50 ChEMBL;BindingDB
Q9F663 KPC-2 Klebsiella pneumoniae Pathogen PF13354 6.4 IC50 ChEMBL;BindingDB
P13661 OXA-1 Escherichia coli Pathogen PF00905 6.4 IC50 BindingDB
B8R6A5 penB1 Burkholderia cenocepacia Pathogen PF13354 6.3 IC50 ChEMBL;BindingDB
P00807 blaZ Staphylococcus aureus Pathogen PF13354 PF08139 6.3 IC50 ChEMBL;BindingDB
P00808 penP Bacillus licheniformis Pathogen PF13354 6.3 IC50 ChEMBL;BindingDB
DrugBank Target Actions (8)
Target Gene Target Name Action Type
P00807 blaZ Beta-lactamase inhibitor targets
P0AD63 bla Beta-lactamase SHV-1 inhibitor targets
P18251 P18251 Beta-lactamase Ohio-1 inhibitor targets
P62594 P62594 Beta-lactamase TEM inhibitor targets
Q4U2R8 SLC22A6 Solute carrier family 22 member 6 inhibitor transporters
Q8TCC7 SLC22A8 Organic anion transporter 3 inhibitor transporters
Q4U2R8 SLC22A6 Solute carrier family 22 member 6 substrate transporters
Q8TCC7 SLC22A8 Organic anion transporter 3 substrate transporters