Molecule Details
| InChIKey | LPQZKKCYTLCDGQ-WEDXCCLWSA-N |
|---|---|
| Compound Name | Tazobactam |
| Canonical SMILES | C[C@]1(Cn2ccnn2)[C@H](C(=O)O)N2C(=O)C[C@H]2S1(=O)=O |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 15 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.14 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB01606 |
|---|---|
| Drug Name | Tazobactam |
| CAS Number | 89786-04-9 |
| Groups | approved investigational |
| ATC Codes | J01CG02 |
| Description | Tazobactam is an antibiotic of the beta-lactamase inhibitor class that prevents the breakdown of other antibiotics by beta-lactamase enzyme producing organisms. It is combined with [Piperacillin] and [Ceftolozane] for the treatment of a variety of bacterial infections. Piperacillin-tazobactam was in... |
Categories: Amides Anti-Infective Agents Antibacterials for Systemic Use Antiinfectives for Systemic Use Aza Compounds Azabicyclo Compounds Beta-Lactam Antibacterials Enzyme Inhibitors Heterocyclic Compounds, Fused-Ring Lactams OAT1/SLC22A6 Substrates OAT1/SLC22A6 inhibitors OAT3/SLC22A8 Inhibitors OAT3/SLC22A8 Substrates Sulfones Sulfur Compounds beta-Lactamase Inhibitors beta-Lactams
Cross-references: BindingDB: 50053173 ChEBI: 9421 CHEMBL404 ChemSpider: 110216 Drugs Product Database (DPD): 11242 C07771 D00660 PDB: TAZ PharmGKB: PA164764504 PubChem:123630 PubChem:46508088 RxCUI: 37617 Therapeutic Targets Database: DAP000926 Wikipedia: Tazobactam ZINC: ZINC000003787060
Target Activities (15)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q9EXV5 | blaUOE-1 | Escherichia coli | Pathogen | PF13354 | 8.7 | IC50 | ChEMBL;BindingDB |
| Q2XPY6 | blaCTX-M-53 | Salmonella enterica subsp. enterica serovar Westhampton | Pathogen | PF13354 | 8.7 | IC50 | ChEMBL;BindingDB |
| A1E3K9 | blaSCO-1 | Escherichia coli | Pathogen | PF13354 | 8.0 | IC50 | ChEMBL;BindingDB |
| Q46991 | imiA | Enterobacter cloacae | Pathogen | PF13354 | 7.5 | IC50 | ChEMBL;BindingDB |
| Q670S6 | Pseudomonas luteola | Pathogen | PF13354 | 7.4 | IC50 | ChEMBL;BindingDB | |
| D1MIX9 | blaGES-13 | Pseudomonas aeruginosa | Pathogen | PF13354 | 7.2 | IC50 | ChEMBL;BindingDB |
| Q6W9J1 | blaTEM-1 | Enterobacter cloacae | Pathogen | PF13354 | 7.2 | IC50 | ChEMBL |
| A0ZX81 | blaSHV-72 | Klebsiella pneumoniae | Pathogen | PF13354 | 7.1 | IC50 | ChEMBL;BindingDB |
| Q8RT60 | bla OXY | Klebsiella oxytoca | Pathogen | PF13354 | 7.0 | IC50 | BindingDB |
| Q6GWS8 | blaTEM-125 | Escherichia coli | Pathogen | PF13354 | 6.6 | IC50 | ChEMBL;BindingDB |
| Q9F663 | KPC-2 | Klebsiella pneumoniae | Pathogen | PF13354 | 6.4 | IC50 | ChEMBL;BindingDB |
| P13661 | OXA-1 | Escherichia coli | Pathogen | PF00905 | 6.4 | IC50 | BindingDB |
| B8R6A5 | penB1 | Burkholderia cenocepacia | Pathogen | PF13354 | 6.3 | IC50 | ChEMBL;BindingDB |
| P00807 | blaZ | Staphylococcus aureus | Pathogen | PF13354 PF08139 | 6.3 | IC50 | ChEMBL;BindingDB |
| P00808 | penP | Bacillus licheniformis | Pathogen | PF13354 | 6.3 | IC50 | ChEMBL;BindingDB |
DrugBank Target Actions (8)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P00807 | blaZ | Beta-lactamase | inhibitor | targets |
| P0AD63 | bla | Beta-lactamase SHV-1 | inhibitor | targets |
| P18251 | P18251 | Beta-lactamase Ohio-1 | inhibitor | targets |
| P62594 | P62594 | Beta-lactamase TEM | inhibitor | targets |
| Q4U2R8 | SLC22A6 | Solute carrier family 22 member 6 | inhibitor | transporters |
| Q8TCC7 | SLC22A8 | Organic anion transporter 3 | inhibitor | transporters |
| Q4U2R8 | SLC22A6 | Solute carrier family 22 member 6 | substrate | transporters |
| Q8TCC7 | SLC22A8 | Organic anion transporter 3 | substrate | transporters |