InChIKey	LOUPRKONTZGTKE-LHHVKLHASA-N
Compound Name	Quinidine
Canonical SMILES	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Cross-Family
Avg pChEMBL	6.76
Source	ChEMBL;BindingDB

DrugBank ID	DB00908
Drug Name	Quinidine
CAS Number	56-54-2
Groups	approved
ATC Codes	C01BA01 C01BA51 C01BA71
Description	Quinidine is a D-isomer of [quinine] present in the bark of the Cinchona tree and similar plant species. This alkaloid was first described in 1848 and has a long history as an antiarrhythmic medication.[A38016,A250050] Quinidine is considered the first antiarrhythmic drug (class Ia) and is moderatel...

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Categories: Adrenergic Agents Adrenergic Antagonists Adrenergic alpha-1 Receptor Antagonists Adrenergic alpha-Antagonists Agents producing tachycardia Agents that produce hypertension Agents that produce neuromuscular block (indirect) Agents that reduce seizure threshold Alkaloids Anti-Infective Agents Antiarrhythmic agents Antiarrhythmics, Class I Antiarrhythmics, Class Ia Anticholinergic Agents Antimalarials Antiparasitic Agents Antiprotozoals BSEP/ABCB11 Inhibitors Biological Products Biopolymers Carbohydrates Cardiac Therapy Cardiovascular Agents Cholinergic Agents Cinchona Alkaloids Complex Mixtures Compounds used in a research, industrial, or household setting Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (strong) Cytochrome P-450 CYP2B6 Inhibitors Cytochrome P-450 CYP2B6 Inhibitors (strength unknown) Cytochrome P-450 CYP2C8 Inducers Cytochrome P-450 CYP2C8 Inducers (weak) Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (weak) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (moderate) Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strong) Cytochrome P-450 CYP2E1 Substrates Cytochrome P-450 CYP2E1 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (weak) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 CYP3A7 Substrates with a Narrow Therapeutic Index Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Drugs causing inadvertant photosensitivity Drugs that are Mainly Renally Excreted Drugs that are Mainly Renally Excreted with a Narrow Therapeutic Index Enzyme Inhibitors Heterocyclic Compounds, Fused-Ring Highest Risk QTc-Prolonging Agents Macromolecular Substances Membrane Transport Modulators Muscarinic Antagonists Narrow Therapeutic Index Drugs Negative Inotrope Neurotransmitter Agents OAT3/SLC22A8 Inhibitors OATP1B1/SLCO1B1 Inhibitors OCT1 inhibitors OCT2 Inhibitors P-glycoprotein inhibitors P-glycoprotein substrates P-glycoprotein substrates with a Narrow Therapeutic Index Pharmaceutical Preparations Photosensitizing Agents Plant Extracts Plant Preparations Polymers Polysaccharides QTc Prolonging Agents Quinolines Quinuclidines Sodium Channel Blockers Voltage-Gated Sodium Channel Blockers

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Cross-references: BindingDB: 50121975 ChEBI: 28593 CHEMBL1294 ChemSpider: 389880 Drugs Product Database (DPD): 6714 Guide to Pharmacology: 2342 IUPHAR: 2342 C06527 D08458 PDB: QDN PharmGKB: PA451209 PubChem:441074 PubChem:46505356 RxCUI: 9068 Therapeutic Targets Database: DAP000515 Wikipedia: Quinidine ZINC: ZINC000003831405