Molecule Details
InChIKeyLOCWELCIOZHZHE-UHFFFAOYSA-N
Compound Name3-[(2,4-dichlorophenyl)methylamino]-4-(1H-indazol-5-ylamino)cyclobut-3-ene-1,2-dione
Canonical SMILESO=c1c(NCc2ccc(Cl)cc2Cl)c(Nc2ccc3[nH]ncc3c2)c1=O
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)11
Pfam Stratification Cross-Family
Avg pChEMBL7.25
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (11)
Target Gene Organism Category Pfam pChEMBL Type Source
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 8.5 Ki ChEMBL
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 7.9 Ki ChEMBL
P17612 PRKACA Homo sapiens Human PF00069 7.8 Ki ChEMBL
O96017 CHEK2 Homo sapiens Human PF00498 PF00069 7.4 Ki ChEMBL
P51812 RPS6KA3 Homo sapiens Human PF00069 PF00433 7.4 Ki ChEMBL
Q13627 DYRK1A Homo sapiens Human PF00069 7.3 Ki ChEMBL
Q05655 PRKCD Homo sapiens Human PF00130 PF21494 PF00069 PF00433 7.0 Ki ChEMBL
Q5VT25 CDC42BPA Homo sapiens Human PF00130 PF00780 PF08826 PF15796 PF25346 PF00069 PF00433 7.0 Ki ChEMBL
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 6.8 Ki ChEMBL
O60674 JAK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.4 Ki ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 6.3 Ki ChEMBL