InChIKey	LNEPOXFFQSENCJ-UHFFFAOYSA-N
Compound Name	Haloperidol
Canonical SMILES	O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	33
Pfam Stratification	Cross-Family
Avg pChEMBL	7.13
Source	BindingDB;ChEMBL;TTD_MultiTarget

DrugBank ID	DB00502
Drug Name	Haloperidol
CAS Number	52-86-8
Groups	approved investigational
ATC Codes	N05AD01
Description	Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide.[A180616] While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain,[A27477] it exerts its antipsychotic effect th...

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Categories: Agents that reduce seizure threshold Anti-Dyskinesia Agents Antidepressive Agents Antiemetics Antipsychotic Agents Antipsychotic Agents (First Generation [Typical]) Autonomic Agents Butyrophenone Derivatives Butyrophenones Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP1A1 Substrates Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strength unknown) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (moderate) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dopamine Agents Dopamine Antagonists Dopamine D2 Receptor Antagonists Drugs causing inadvertant photosensitivity Drugs that are Mainly Renally Excreted Gastrointestinal Agents Hyperglycemia-Associated Agents Ketones Moderate Risk QTc-Prolonging Agents NMDA Receptor Antagonists Nervous System Neurotoxic agents Neurotransmitter Agents P-glycoprotein inhibitors P-glycoprotein substrates Peripheral Nervous System Agents Photosensitizing Agents Psycholeptics Psychotropic Drugs QTc Prolonging Agents Serotonin 5-HT1 Receptor Antagonists Serotonin 5-HT1A Receptor Antagonists Serotonin 5-HT2 Receptor Antagonists Serotonin 5-HT2A Receptor Antagonists Serotonin 5-HT2C Receptor Antagonists Serotonin Agents Serotonin Receptor Antagonists Tranquilizing Agents UGT1A9 Substrates

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Cross-references: BindingDB: 50019951 ChEBI: 5613 CHEMBL54 ChemSpider: 3438 Drugs Product Database (DPD): 10146 Guide to Pharmacology: 86 IUPHAR: 86 C01814 D00136 PDB: GMJ PharmGKB: PA449841 PubChem:3559 PubChem:46508794 RxCUI: 5093 Therapeutic Targets Database: DAP000313 Wikipedia: Haloperidol ZINC: ZINC000000537822