Molecule Details
| InChIKey | LLPOLZWFYMWNKH-CMKMFDCUSA-N |
|---|---|
| Canonical SMILES | COc1ccc2c3c1O[C@H]1C(=O)CC[C@H]4[C@@H](C2)N(C)CC[C@]314 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.3 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB00956 |
|---|---|
| Drug Name | Hydrocodone |
| CAS Number | 125-29-1 |
| Groups | approved illicit investigational |
| ATC Codes | R05DA03 N02AJ22 N02AJ23 |
| Description | Hydrocodone is a synthetic opioid derivative of codeine.[T116] It is commonly used in combination with [acetaminophen] to control moderate to severe pain. Historically, hydrocodone has been used as a cough suppressant although this has largely been replaced by [dextromethorphan] in current cough and... |
Categories: Alkaloids Analgesics Antitussive Agents Central Nervous System Agents Central Nervous System Depressants Cough and Cold Preparations Cytochrome P-450 CYP2B6 Substrates Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Substrates Heterocyclic Compounds, Fused-Ring Morphinans Morphine Derivatives Narcotics Nervous System Opiate Alkaloids Opioid Agonist Opioids Opium Alkaloids and Derivatives Peripheral Nervous System Agents Respiratory System Agents Semi-synthetic Opioids Sensory System Agents Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
Cross-references: BindingDB: 50386689 ChEBI: 5779 CHEMBL1457 ChemSpider: 4447623 Drugs Product Database (DPD): 20386 C08024 D08045 PharmGKB: PA449900 PubChem:5284569 PubChem:46506225 RxCUI: 5489 Therapeutic Targets Database: DAP000253 Wikipedia: Hydrocodone ZINC: ZINC000001280665
Target Activities (2)
DrugBank Target Actions (7)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P08684 | CYP3A4 | Cytochrome P450 3A4 | substrate | enzymes |
| P10635 | CYP2D6 | Cytochrome P450 2D6 | substrate | enzymes |
| P20813 | CYP2B6 | Cytochrome P450 2B6 | substrate | enzymes |
| P33261 | CYP2C19 | Cytochrome P450 2C19 | substrate | enzymes |
| P35372 | OPRM1 | Mu-type opioid receptor | agonist | targets |
| P41143 | OPRD1 | Delta-type opioid receptor | agonist | targets |
| Q99720 | SIGMAR1 | Sigma non-opioid intracellular receptor 1 | ligand | targets |