Molecule Details
InChIKeyLLPOLZWFYMWNKH-CMKMFDCUSA-N
Canonical SMILESCOc1ccc2c3c1O[C@H]1C(=O)CC[C@H]4[C@@H](C2)N(C)CC[C@]314
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Homologous
Avg pChEMBL7.3
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB00956
Drug NameHydrocodone
CAS Number125-29-1
Groups approved illicit investigational
ATC Codes R05DA03 N02AJ22 N02AJ23
DescriptionHydrocodone is a synthetic opioid derivative of codeine.[T116] It is commonly used in combination with [acetaminophen] to control moderate to severe pain. Historically, hydrocodone has been used as a cough suppressant although this has largely been replaced by [dextromethorphan] in current cough and...

Categories: Alkaloids Analgesics Antitussive Agents Central Nervous System Agents Central Nervous System Depressants Cough and Cold Preparations Cytochrome P-450 CYP2B6 Substrates Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Substrates Heterocyclic Compounds, Fused-Ring Morphinans Morphine Derivatives Narcotics Nervous System Opiate Alkaloids Opioid Agonist Opioids Opium Alkaloids and Derivatives Peripheral Nervous System Agents Respiratory System Agents Semi-synthetic Opioids Sensory System Agents Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
Cross-references: BindingDB: 50386689 ChEBI: 5779 CHEMBL1457 ChemSpider: 4447623 Drugs Product Database (DPD): 20386 C08024 D08045 PharmGKB: PA449900 PubChem:5284569 PubChem:46506225 RxCUI: 5489 Therapeutic Targets Database: DAP000253 Wikipedia: Hydrocodone ZINC: ZINC000001280665
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
P35372 OPRM1 Homo sapiens Human PF00001 8.0 Ki ChEMBL;BindingDB
P41145 OPRK1 Homo sapiens Human PF00001 6.6 Ki ChEMBL;BindingDB
DrugBank Target Actions (7)
Target Gene Target Name Action Type
P08684 CYP3A4 Cytochrome P450 3A4 substrate enzymes
P10635 CYP2D6 Cytochrome P450 2D6 substrate enzymes
P20813 CYP2B6 Cytochrome P450 2B6 substrate enzymes
P33261 CYP2C19 Cytochrome P450 2C19 substrate enzymes
P35372 OPRM1 Mu-type opioid receptor agonist targets
P41143 OPRD1 Delta-type opioid receptor agonist targets
Q99720 SIGMAR1 Sigma non-opioid intracellular receptor 1 ligand targets