InChIKey	LJVAJPDWBABPEJ-PNUFFHFMSA-N
Compound Name	Telithromycin
Canonical SMILES	CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(-c4cccnc4)c3)C(=O)O[C@]12C
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	59
Pfam Stratification	Cross-Family
Avg pChEMBL	8.22
Source	ChEMBL

DrugBank ID	DB00976
Drug Name	Telithromycin
CAS Number	191114-48-4
Groups	approved
ATC Codes	J01FA15
Description	Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth ...

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Categories: Anti-Bacterial Agents Anti-Infective Agents Antibacterials for Systemic Use Antiinfectives for Systemic Use Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strong) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Inhibitors Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Erythromycin and similars Ketolide Antibacterial Ketolides Lactones Macrolides Macrolides, Lincosamides and Streptogramins Moderate Risk QTc-Prolonging Agents OATP1B1/SLCO1B1 Inhibitors OATP1B3 inhibitors Polyketides Protein Synthesis Inhibitors QTc Prolonging Agents

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Cross-references: BindingDB: 50378137 ChEBI: 29688 CHEMBL1136 ChemSpider: 2273373 Drugs Product Database (DPD): 13168 C12009 D01078 PDB: TEL PharmGKB: PA10202 PubChem:3002190 PubChem:46504510 RxCUI: 274786 Therapeutic Targets Database: DAP000109 Wikipedia: Telithromycin ZINC: ZINC000009574770