Molecule Details
| InChIKey | LIRYPHYGHXZJBZ-UHFFFAOYSA-N |
|---|---|
| Canonical SMILES | CC(=O)Nc1cccc(-n2c(=O)n(C3CC3)c(=O)c3c(Nc4ccc(I)cc4F)n(C)c(=O)c(C)c32)c1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 8.65 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB08911 |
|---|---|
| Drug Name | Trametinib |
| CAS Number | 871700-17-3 |
| Groups | approved investigational |
| ATC Codes | L01EE01 |
| Description | Trametinib is an orally bioavailable mitogen-activated extracellular signal-regulated kinase 1 (MEK1) and MEK2 inhibitor.[A258298,A258293] It was first approved by the FDA in May 2013 for the treatment of melanoma.[A258298] It was later approved by Health Canada on July 18, 2013 [L45588] and by the ... |
Categories: Antineoplastic Agents Antineoplastic and Immunomodulating Agents Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (strong) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Drugs that are Mainly Renally Excreted Enzyme Inhibitors Kinase Inhibitor MAP Kinase Kinase 1, antagonists & inhibitors MAP Kinase Kinase 2, antagonists & inhibitors Mitogen-activated protein kinase (MEK) inhibitors Narrow Therapeutic Index Drugs Protein Kinase Inhibitors Pyridines Pyrimidines
Cross-references: BindingDB: 50531540 ChEBI: 75998 CHEMBL2103875 ChemSpider: 9881833 Drugs Product Database (DPD): 22128 D10175 PharmGKB: PA166115364 PubChem:11707110 PubChem:175427149 RxCUI: 1425099 Wikipedia: Trametinib ZINC: ZINC000043100709
Target Activities (2)
DrugBank Target Actions (5)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P08684 | CYP3A4 | Cytochrome P450 3A4 | inducer | enzymes |
| P10632 | CYP2C8 | Cytochrome P450 2C8 | inhibitor | enzymes |
| P08684 | CYP3A4 | Cytochrome P450 3A4 | substrate | enzymes |
| P36507 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | inhibitor | targets |
| Q02750 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | inhibitor | targets |