Molecule Details
InChIKeyLHQWPYOYDRVMFI-UHFFFAOYSA-N
Compound Name1-(1H-indol-3-yl)-3-[(5-isoquinolin-6-yl-3-pyridinyl)oxy]propan-2-amine
Canonical SMILESNC(COc1cncc(-c2ccc3cnccc3c2)c1)Cc1c[nH]c2ccccc12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)21
Pfam Stratification Cross-Family
Avg pChEMBL7.36
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (21)
Target Gene Organism Category Pfam pChEMBL Type Source
Q9HAZ1 CLK4 Homo sapiens Human PF00069 9.0 Ki ChEMBL
Q05397 PTK2 Homo sapiens Human PF21477 PF00373 PF18038 PF03623 PF07714 8.7 Ki ChEMBL
Q9Y463 DYRK1B Homo sapiens Human PF00069 8.7 Ki ChEMBL
P49760 CLK2 Homo sapiens Human PF00069 8.6 Ki ChEMBL
Q04759 PRKCQ Homo sapiens Human PF00130 PF21494 PF00069 PF00433 8.5 Ki ChEMBL
Q13627 DYRK1A Homo sapiens Human PF00069 8.5 Ki ChEMBL
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 8.3 Ki ChEMBL
P51817 PRKX Homo sapiens Human PF00069 8.2 Ki ChEMBL
Q16513 PKN2 Homo sapiens Human PF02185 PF00069 PF00433 7.5 Ki ChEMBL
Q00535 CDK5 Homo sapiens Human PF00069 7.1 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 6.8 Ki ChEMBL
P51812 RPS6KA3 Homo sapiens Human PF00069 PF00433 6.8 Ki ChEMBL
O94806 PRKD3 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.7 Ki ChEMBL
P50750 CDK9 Homo sapiens Human PF00069 6.7 Ki ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 6.6 Ki ChEMBL
P49336 CDK8 Homo sapiens Human PF00069 6.5 Ki ChEMBL
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.4 Ki ChEMBL
Q9UQM7 CAMK2A Homo sapiens Human PF08332 PF00069 6.4 Ki ChEMBL
P11309 PIM1 Homo sapiens Human PF00069 6.3 Ki ChEMBL
O43293 DAPK3 Homo sapiens Human PF00069 6.2 Ki ChEMBL
Q5S007 LRRK2 Homo sapiens Human PF23745 PF23744 PF23748 PF16095 PF25497 PF13855 PF00069 PF08477 6.0 Ki ChEMBL