Molecule Details
InChIKeyLHQWPYOYDRVMFI-QFIPXVFZSA-N
Compound Name(2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridin-3-yl)oxy-propan-2-amine
Canonical SMILESN[C@H](COc1cncc(-c2ccc3cnccc3c2)c1)Cc1c[nH]c2ccccc12
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)10
Pfam Stratification Cross-Family
Avg pChEMBL7.7
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
Target Activities (10)
Target Gene Organism Category Pfam pChEMBL Type Source
P31749 AKT1 Homo sapiens Human PF00169 PF00069 PF00433 8.7 IC50 ChEMBL;BindingDB
P17612 PRKACA Homo sapiens Human PF00069 8.7 IC50 ChEMBL
P22612 PRKACG Homo sapiens Human PF00069 8.7 IC50 ChEMBL
P22694 PRKACB Homo sapiens Human PF00069 8.7 IC50 ChEMBL
P31751 AKT2 Homo sapiens Human PF00169 PF00069 PF00433 8.2 IC50 ChEMBL;BindingDB
Q9Y243 AKT3 Homo sapiens Human PF00169 PF00069 PF00433 7.5 IC50 ChEMBL;BindingDB
P06493 CDK1 Homo sapiens Human PF00069 7.0 pIC50 TTD_MultiTarget
P18505 GABRB1 Homo sapiens Human PF02931 PF02932 7.0 pIC50 TTD_MultiTarget
P05129 PRKCG Homo sapiens Human PF00130 PF00168 PF00069 PF00433 6.6 IC50 ChEMBL;BindingDB
P28482 MAPK1 Homo sapiens Human PF00069 6.0 IC50 ChEMBL