Molecule Details
| InChIKey | LGHQSFKSGYAABV-CMCWBKRRSA-N |
|---|---|
| Compound Name | (2S,3S,4R,5R)-5-(4-amino-5-cyanopyrrolo[2,3-d]pyrimidin-7-yl)-N-[2-(azetidin-1-yl)quinolin-7-yl]-3,4-dihydroxyoxolane-2-carboxamide |
| Canonical SMILES | N#Cc1cn([C@@H]2O[C@H](C(=O)Nc3ccc4ccc(N5CCC5)nc4c3)[C@@H](O)[C@H]2O)c2ncnc(N)c12 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.25 |
| Source | ChEMBL |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q86U44 | METTL3 | Homo sapiens | Human | PF05063 | 8.0 | IC50 | ChEMBL |
| O14744 | PRMT5 | Homo sapiens | Human | PF05185 PF17286 PF17285 | 7.0 | IC50 | ChEMBL |
| P36888 | FLT3 | Homo sapiens | Human | PF00047 PF07714 | 7.0 | IC50 | ChEMBL |
| Q9BQA1 | WDR77 | Homo sapiens | Human | PF00400 | 7.0 | IC50 | ChEMBL |