Molecule Details
InChIKeyLGGHDPFKSSRQNS-UHFFFAOYSA-N
Compound NameTariquidar
Canonical SMILESCOc1cc2c(cc1OC)CN(CCc1ccc(NC(=O)c3cc(OC)c(OC)cc3NC(=O)c3cnc4ccccc4c3)cc1)CC2
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Homologous
Avg pChEMBL6.87
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB06240
Drug NameTariquidar
CAS Number206873-63-4
Groups investigational
ATC Codes nan
Descriptionnan
Categories: Drug Resistance, Multiple Heterocyclic Compounds, Fused-Ring P-glycoprotein inhibitors
Cross-references: BindingDB: 50075373 CHEMBL348475 ChemSpider: 130650 PDB: R1H Wikipedia: Tariquidar ZINC: ZINC000004214704
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
P08183 ABCB1 Homo sapiens Human PF00664 PF00005 7.5 IC50 ChEMBL;BindingDB
Q9UNQ0 ABCG2 Homo sapiens Human PF01061 PF19055 PF00005 6.3 IC50 ChEMBL;BindingDB
DrugBank Target Actions (2)
Target Gene Target Name Action Type
P08183 ABCB1 ATP-dependent translocase ABCB1 modulator targets
P08183 ABCB1 ATP-dependent translocase ABCB1 inhibitor transporters