Molecule Details
InChIKeyLFWCJABOXHSRGC-UHFFFAOYSA-N
Canonical SMILESCOc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccnc(-c3nnn[nH]3)c2)nc1OCCO
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Homologous
Avg pChEMBL8.04
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB06677
Drug NameClazosentan
CAS Number180384-56-9
Groups investigational
ATC Codes C04AX33
Descriptionnan
Categories: Amides Peripheral Vasodilators Receptor, Endothelin A Sulfones Sulfur Compounds Vasospasm, Intracranial
Cross-references: BindingDB: 50066370 CHEMBL109648 ChemSpider: 4938283 ZINC: ZINC000003939238
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
P25101 EDNRA Homo sapiens Human PF00001 9.3 IC50 ChEMBL;BindingDB
P24530 EDNRB Homo sapiens Human PF00001 6.8 IC50 ChEMBL;BindingDB
DrugBank Target Actions (1)
Target Gene Target Name Action Type
P25101 EDNRA Endothelin-1 receptor antagonist targets