Molecule Details
| InChIKey | KYCKKSZMVINEPM-UHFFFAOYSA-N |
|---|---|
| Compound Name | [6-[2-(Butylamino)-4-[(4-hydroxycyclohexyl)amino]pyrimidin-5-yl]-3-pyridinyl]-(4-methylpiperazin-1-yl)methanone |
| Canonical SMILES | CCCCNc1ncc(-c2ccc(C(=O)N3CCN(C)CC3)cn2)c(NC2CCC(O)CC2)n1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.87 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q12866 | MERTK | Homo sapiens | Human | PF00041 PF00047 PF13927 PF07714 | 9.0 | IC50 | ChEMBL;BindingDB |
| P36888 | FLT3 | Homo sapiens | Human | PF00047 PF07714 | 8.1 | IC50 | ChEMBL;BindingDB |
| Q14393 | GAS6 | Homo sapiens | Human | PF12662 PF07645 PF00594 PF12661 PF00054 PF02210 | 7.5 | IC50 | ChEMBL;BindingDB |
| Q06418 | TYRO3 | Homo sapiens | Human | PF00041 PF07679 PF07714 | 6.9 | IC50 | ChEMBL;BindingDB |