Molecule Details
InChIKeyKXDIHAQCVNNLIB-UHFFFAOYSA-N
Compound NameMK-4965
Canonical SMILESN#Cc1cc(Cl)cc(Oc2cc(OCc3n[nH]c4nc(N)ccc34)ccc2Cl)c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Homologous
Avg pChEMBL9.46
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB08460
Drug NameMK-4965
CAS Number920035-77-4
Groups experimental
ATC Codes nan
DescriptionMK-4965 is an HIV-1 reverse transcriptase inhibitor.
Categories: HIV Reverse Transcriptase, antagonists & inhibitors
Cross-references: CHEMBL489586 ChemSpider: 13173831 PDB: R8E PubChem:16045418 PubChem:99444931 ZINC: ZINC000034891728
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
Q9WKE8 reverse transcriptase Human immunodeficiency virus type 1 Pathogen PF00078 9.5 IC50 BindingDB
Q72547 pol Human immunodeficiency virus type 1 Pathogen PF00075 PF00078 PF06815 PF06817 9.4 IC50 ChEMBL
DrugBank Target Actions (1)
Target Gene Target Name Action Type
P04585 gag-pol Gag-Pol polyprotein binder targets