N-[4-(4-amino-6-bromothieno[2,3-d]pyrimidin-5-yl)phenyl]-2-(3-chlorophenyl)acetamide

InChIKey	`KWSZYBNXNYRQCC-UHFFFAOYSA-N`
Compound Name	N-[4-(4-amino-6-bromothieno[2,3-d]pyrimidin-5-yl)phenyl]-2-(3-chlorophenyl)acetamide
Canonical SMILES	`Nc1ncnc2sc(Br)c(-c3ccc(NC(=O)Cc4cccc(Cl)c4)cc3)c12`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	21
Pfam Stratification	Cross-Family
Avg pChEMBL	6.45
Source	ChEMBL

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P36888	FLT3	Homo sapiens	Human	PF00047 PF07714	8.2	Ki	ChEMBL
P07333	CSF1R	Homo sapiens	Human	PF00047 PF25305 PF07714	7.6	Ki	ChEMBL
Q96GD4	AURKB	Homo sapiens	Human	PF00069	7.1	Ki	ChEMBL
P17948	FLT1	Homo sapiens	Human	PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854	7.0	Ki	ChEMBL
P06241	FYN	Homo sapiens	Human	PF07714 PF00017 PF00018	6.6	Ki	ChEMBL
P07332	FES	Homo sapiens	Human	PF00611 PF07714 PF00017	6.5	Ki	ChEMBL
P30530	AXL	Homo sapiens	Human	PF00041 PF13927 PF07714	6.5	Ki	ChEMBL
P51451	BLK	Homo sapiens	Human	PF07714 PF00017 PF00018	6.5	Ki	ChEMBL
O14965	AURKA	Homo sapiens	Human	PF00069	6.3	Ki	ChEMBL
P35916	FLT4	Homo sapiens	Human	PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854	6.3	Ki	ChEMBL
P07948	LYN	Homo sapiens	Human	PF07714 PF00017 PF00018	6.2	Ki	ChEMBL
P35968	KDR	Homo sapiens	Human	PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854	6.2	Ki	ChEMBL
Q9H4B4	PLK3	Homo sapiens	Human	PF00069 PF00659	6.2	Ki	ChEMBL
P51617	IRAK1	Homo sapiens	Human	PF00531 PF00069	6.1	Ki	ChEMBL
Q06187	BTK	Homo sapiens	Human	PF00779 PF00169 PF07714 PF00017 PF00018	6.1	Ki	ChEMBL
Q16288	NTRK3	Homo sapiens	Human	PF07679 PF00047 PF13855 PF16920 PF01462 PF07714	6.1	Ki	ChEMBL
P11362	FGFR1	Homo sapiens	Human	PF07679 PF00047 PF07714	6.0	Ki	ChEMBL
P42679	MATK	Homo sapiens	Human	PF07714 PF00017 PF00018	6.0	Ki	ChEMBL
P53667	LIMK1	Homo sapiens	Human	PF00412 PF00595 PF07714	6.0	Ki	ChEMBL
Q9HAZ1	CLK4	Homo sapiens	Human	PF00069	6.0	Ki	ChEMBL
Q9Y4K4	MAP4K5	Homo sapiens	Human	PF00780 PF00069	6.0	Ki	ChEMBL