Molecule Details
| InChIKey | KWSRBEPOLXYHOX-UHFFFAOYSA-N |
|---|---|
| Compound Name | 1-Tert-butyl-3-[6-(3,5-dimethoxyphenyl)-2-(3-morpholin-4-ylpropylamino)pyrido[2,3-d]pyrimidin-7-yl]urea |
| Canonical SMILES | COc1cc(OC)cc(-c2cc3cnc(NCCCN4CCOCC4)nc3nc2NC(=O)NC(C)(C)C)c1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.52 |
| Source | ChEMBL |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P11362 | FGFR1 | Homo sapiens | Human | PF07679 PF00047 PF07714 | 7.5 | IC50 | ChEMBL |
| P21802 | FGFR2 | Homo sapiens | Human | PF07679 PF13927 PF07714 | 7.5 | IC50 | ChEMBL |
| P22455 | FGFR4 | Homo sapiens | Human | PF07679 PF13927 PF07714 | 7.5 | IC50 | ChEMBL |
| P22607 | FGFR3 | Homo sapiens | Human | PF21165 PF07679 PF13927 PF07714 | 7.5 | IC50 | ChEMBL |